School of Biomedical Engineering, Institute of Technology, Banaras Hindu University, Varanasi, India.
Int Rev Neurobiol. 2012;102:107-46. doi: 10.1016/B978-0-12-386986-9.00005-3.
Oxidative stress in the central nervous system is one of the key players for neurodegeneration. Thus, antioxidants could play important roles in treating several neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and aging-related brain disorders. This review is focused on the new developments in oxidative stress-induced neurodegeneration. Further, based on our own investigations, new roles of quercetin, an antioxidant compound in hypoxia and ischemia induced neuroprotection in relation to suppression of oxidative stress, improvement in behavioral function, reduction in infarct volume, brain swelling, and cellular injury in both in vivo and in vitro models are discussed. Our new findings clearly suggest that antioxidant compounds have potential role in therapeutic strategies to treat neurodegenerative diseases in clinical settings.
中枢神经系统中的氧化应激是神经退行性变的关键因素之一。因此，抗氧化剂在治疗几种神经退行性疾病方面可能发挥重要作用，包括阿尔茨海默病、帕金森病和与衰老相关的脑紊乱。本综述重点介绍了氧化应激诱导的神经退行性变的新进展。此外，基于我们自己的研究结果，讨论了槲皮素（一种抗氧化化合物）在缺氧和缺血诱导的神经保护中的新作用，其与抑制氧化应激、改善行为功能、减少梗死体积、脑肿胀和细胞损伤有关，在体内和体外模型中均有涉及。我们的新发现清楚地表明，抗氧化化合物在治疗神经退行性疾病的临床策略中具有潜在的作用。
