Yoo Han Sang, Shin Sung Jae
Department of Infectious Diseases, College of Veterinary Medicine, Research Institute for Veterinary Science and BK21 for Veterinary Science, Seoul National University, Seoul 151-742, South Korea.
Vet Immunol Immunopathol. 2012 Jul 15;148(1-2):23-8. doi: 10.1016/j.vetimm.2012.06.005. Epub 2012 Jun 9.
Bovine paratuberculosis (Johne's disease), a chronic and debilitating disease of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP), is a major cause of chronic ruminant enteritis. A national eradication program has been in place in South Korea since the first report of the disease in 1967; however, only limited data on bovine paratuberculosis in South Korea are available. Some research, such as investigations of the reactivity of animal sera against MAP antigens, has been done in localized areas and in limited animal species. Compared with the worldwide situation, the development of diagnostic methods in South Korea has shown similar results even though some data were obtained from international collaborative studies. MAP is considered by some to be zoonotic, noting an association with Crohn's disease, although this issue is still controversial; however, research into this association is limited. Decisions based on disease priorities have hampered active progress in research on the disease. In this paper, we reviewed the available results generated from South Korea compared with global research. Finally, we propose a theme for future research.
牛副结核病（约翰氏病）是由副结核分枝杆菌鸟型亚种（MAP）引起的反刍动物慢性消耗性疾病，是慢性反刍动物肠炎的主要病因。自1967年韩国首次报告该病以来，一直在实施全国根除计划；然而，韩国关于牛副结核病的可用数据有限。一些研究，如对动物血清针对MAP抗原的反应性的调查，已在局部地区和有限的动物物种中进行。与全球情况相比，韩国诊断方法的发展取得了类似的结果，尽管一些数据来自国际合作研究。一些人认为MAP是人畜共患病，指出其与克罗恩病有关，尽管这个问题仍有争议；然而，关于这种关联的研究有限。基于疾病优先级的决策阻碍了该病研究的积极进展。在本文中，我们将韩国产生的现有结果与全球研究进行了比较。最后，我们提出了未来研究的主题。
