Department of Physiology of Movements, Bogomoletz Institute of Physiology, Kiev, Ukraine.
Epilepsy Behav. 2012 Aug;24(4):399-402. doi: 10.1016/j.yebeh.2012.05.018. Epub 2012 Jun 28.
Although antiepileptic drugs are often effective in the control of seizures, some patients show little or no improvement. As alternative treatments, different dietary modifications were shown to be beneficial for patients with poor tolerance for AEDS. Previous reports have shown that rice-based oral electrolyte hydration therapy is effective in seizure control in patients with refractory absence seizures. In the present study, using an animal model of absence epilepsy, we showed that the occurrence of spike-and-wave discharges significantly decreases upon switching to electrolyte therapy. We also showed that consumption of solution with the same osmolarity as rice-based oral electrolyte solution leads to a decrease in the number of spike-and-wave discharges per hour. We suggest that the antiepileptic effect of rice-based oral electrolyte hydration therapy can be at least in part due to hyperosmolarity of the ingested solution.
虽然抗癫痫药物通常能有效控制癫痫发作，但有些患者的改善效果甚微或没有改善。作为替代治疗方法，不同的饮食调整已被证明对不能耐受 AEDS 的患者有益。先前的报告表明，基于大米的口服电解质补液疗法对难治性失神发作患者的癫痫控制有效。在本研究中，我们使用失神性癫痫动物模型表明，切换至电解质疗法后，棘波和尖波放电的发生显著减少。我们还表明，摄入与基于大米的口服电解质溶液等渗的溶液会导致每小时棘波和尖波放电次数减少。我们认为，基于大米的口服电解质补液疗法的抗癫痫作用至少部分归因于摄入溶液的高渗性。
