Isala klinieken, Department of Cardiology, Zwolle, The Netherlands.
Maturitas. 2012 Oct;73(2):148-51. doi: 10.1016/j.maturitas.2012.06.006. Epub 2012 Jun 30.
Women with a history of preeclampsia are at increased risk to develop cardiovascular disease (CVD) later in life, especially hypertension is common. In this study we aimed to evaluate electrocardiographic parameters as a proxy for detrimental hypertensive effects and later CVD.
The Preeclampsia Risk EValuation study in FEMales (PREVFEM) study is a prospective cohort study consisting of 339 women with a history of early onset preeclampsia (EOP) and 332 age-matched women without a history if EOP as reference. At ten years post index pregnancy a 12-lead electrocardiogram recording was made.
There were no significant differences in ECG parameters between both groups at 3 9years of age. In our cohort of young women SBP (OR(mmHg): 1.04; 95% CI: 1.2-1.06) as well as DBP (OR(mmHg): 1.04; 95% CI: 1.01-1.07) and stage 2 hypertension (OR: 3.35; 95% CI: 1.16-9.63) were significantly associated with ECG criteria for LVH, but not for other ECG abnormalities. EOP gives no significant adjusted risk on ECG abnormalities compared to women without EOP.
EOP is no significant predictor of non-specific ECG abnormalities. Routine ECG screening in young women after preeclampsia is not recommended in non-hypertensive women, but may be useful when hypertension is present.
有子痫前期病史的女性在以后的生活中发生心血管疾病（CVD）的风险增加，尤其是高血压很常见。本研究旨在评估心电图参数作为有害高血压效应和以后 CVD 的替代指标。
早发型子痫前期风险评估的女性研究（PREVFEM）是一项前瞻性队列研究，纳入 339 例有早发型子痫前期（EOP）病史的女性和 332 例年龄匹配的无 EOP 病史的女性作为对照。在妊娠后 10 年进行 12 导联心电图记录。
在 39 岁时，两组之间的心电图参数没有显著差异。在我们的年轻女性队列中，SBP（每增加 1mmHg 的比值比[OR]：1.04；95%CI：1.2-1.06）和 DBP（每增加 1mmHg 的 OR：1.04；95%CI：1.01-1.07）以及 2 期高血压（OR：3.35；95%CI：1.16-9.63）与心电图左心室肥厚的标准显著相关，但与其他心电图异常无关。与无 EOP 的女性相比，EOP 对心电图异常没有显著的调整风险。
EOP 不是心电图异常的显著预测因素。在非高血压女性中，子痫前期后对年轻女性进行常规心电图筛查不推荐，但在存在高血压时可能有用。
