Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche (IEOS-CNR), Napoli 80131, Italy c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli Federico II, Napoli 80131, Italy.
Biochimie. 2012 Oct;94(10):2082-8. doi: 10.1016/j.biochi.2012.05.018. Epub 2012 Jun 26.
Recent years have seen several advances in our understanding of the functions of adipose tissue regarding not only the energy storage, but also the regulation of complex metabolic and endocrine functions. In this context, leptin and adiponectin, the two most abundant adipocyte products, represent one of the best example of adipocytokines involved in the control of energy expenditure, lipid and carbohydrate metabolism as well as in the regulation of immune responses. Leptin and adiponectin secretion is counter-regulated in vivo, in relation to degree of adiposity, since plasma leptin concentrations are significantly elevated in obese subjects in proportion to body mass index while adiponectin secretion decreases in relation to the amount of adipose tissue. In this review we focus on the main biological activities of leptin and adiponectin on the lipid and carbohydrate metabolism and on their contribute in regulation of innate and adaptive immune responses.
近年来，我们对脂肪组织功能的理解有了一些进展，不仅涉及能量储存，还涉及复杂代谢和内分泌功能的调节。在这种情况下，瘦素和脂联素是脂肪细胞产物中最丰富的两种，它们代表了参与控制能量消耗、脂质和碳水化合物代谢以及调节免疫反应的脂肪细胞因子的最佳例子之一。瘦素和脂联素的分泌在体内是相互拮抗的，与肥胖程度有关，因为肥胖患者的血浆瘦素浓度与体重指数成比例显著升高，而脂联素的分泌则与脂肪组织的量成反比减少。在这篇综述中，我们重点介绍了瘦素和脂联素对脂质和碳水化合物代谢的主要生物学活性，以及它们在调节先天和适应性免疫反应中的作用。
