Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, Uppsala, Sweden.
Neurosci Lett. 2012 Aug 8;523(1):82-6. doi: 10.1016/j.neulet.2012.06.050. Epub 2012 Jun 27.
Previous studies have indicated that both growth hormone (GH) deficiency and diabetes are conditions associated with impairments in learning and memory processes. In this study, we investigated the effect of streptozotocin-induced diabetes on spatial learning in mice using the Barnes maze (BM). The expression of the GH receptor (GHR) gene transcript in areas of the brain associated with learning and memory were examined. The results indicated that the GHR gene transcript is up-regulated in the prefrontal cortex (PFC) of diabetic mice compared to controls. In addition, there was a significant correlation between the expression of GHR mRNA and performance in the BM during the acquisition phase in diabetic but not control mice. These results suggest that diabetes induces an imbalance in the GH/IGF-1 system leading to altered activity in the PFC and associated cognitive deficiencies.
先前的研究表明，生长激素（GH）缺乏症和糖尿病都是与学习和记忆过程受损相关的病症。在这项研究中，我们使用巴恩斯迷宫（BM）研究了链脲佐菌素诱导的糖尿病对小鼠空间学习的影响。检查了与学习和记忆相关的大脑区域中生长激素受体（GHR）基因转录的表达。结果表明，与对照组相比，糖尿病小鼠的前额叶皮层（PFC）中 GHR 基因转录上调。此外，在糖尿病小鼠而不是对照组小鼠的获得阶段，GHR mRNA 的表达与 BM 中的表现之间存在显著相关性。这些结果表明，糖尿病导致 GH/IGF-1 系统失衡，导致 PFC 活动改变和相关认知缺陷。
