Jahangiri Leila, Kesmati Mahnaz, Najafzadeh H
Department of Biology, Faculty of Sciences, Shahid Chamran University, Ahvaz, Iran.
Department of Pharmacology & Toxicology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran.
Basic Clin Neurosci. 2014 Spring;5(2):156-61.
Some studies showed that magnesium has anticonvulsive effect in some animal models. Despite of the availability of well-studied anticonvulsant drugs, this evaluation was not carried on new kind of magnesium supplement, magnesium oxide nanoparticles (nMgO). According to the association between magnesium and convulsion and high prevalence of seizure and epilepsy in diabetics, this study was designed to evaluate the effect of nMgO compared to conventional MgO (cMgO) on strychnine-induced convulsion model in diabetic and non-diabetic mice.
Healthy male albino mice were divided into 10 groups. Diabetes mellitus was induced by streptozotocin in 5 groups. Conventional and nanoparticle MgO (5 and 10mg/kg) were administered to diabetic and non-diabetic mice, then strychnine were injected and onset of convulsions and time of death measured after strychnine administration.
There were no significant differences between normal and diabetic groups in onset of convulsions and time of death. Pretreatment of cMgO did not have anticonvulsant effect in strychnine-induced convulsion in normal and diabetic mice. But nMgO significantly changed convulsion onset and death time after strychnine administration in normal and diabetic status (p < 0.05).
According to our results, it seems that acute administration of nMgO may be important in prevention of convulsion and is more effective than its conventional form in showing anticonvulsive effect that probably is related to the physicochemical properties of nMgO, especially in diabetic subjects, a point that need further investigations.
一些研究表明，镁在某些动物模型中具有抗惊厥作用。尽管有经过充分研究的抗惊厥药物，但尚未对新型镁补充剂——氧化镁纳米颗粒（nMgO）进行此类评估。鉴于镁与惊厥之间的关联以及糖尿病患者中癫痫发作和癫痫的高患病率，本研究旨在评估与传统氧化镁（cMgO）相比，nMgO对糖尿病和非糖尿病小鼠士的宁诱导惊厥模型的影响。
将健康雄性白化小鼠分为10组。其中5组通过链脲佐菌素诱导糖尿病。对糖尿病和非糖尿病小鼠给予传统和纳米颗粒形式的氧化镁（5和10mg/kg），然后注射士的宁，并在注射士的宁后测量惊厥发作时间和死亡时间。
正常组和糖尿病组在惊厥发作时间和死亡时间上无显著差异。cMgO预处理对正常和糖尿病小鼠士的宁诱导惊厥无抗惊厥作用。但nMgO在正常和糖尿病状态下，显著改变了士的宁给药后的惊厥发作时间和死亡时间（p < 0.05）。
根据我们的结果，似乎急性给予nMgO在预防惊厥方面可能很重要，并且在显示抗惊厥作用方面比其传统形式更有效，这可能与nMgO的物理化学性质有关，尤其是在糖尿病患者中，这一点需要进一步研究。
