Kovacs K, Horvath E
Bull Los Angeles Neurol Soc. 1977;42(3-4):92-110.
A new pituitary classification has been developed, based on the histologic, histochemical, immunocytologic and electron microscopic investigation of 207 pituitary adenomas removed surgically from male and female patients of various ages and different clinical symptomatology. Based principally on cytogenesis, the classification attempts to correlate the morphologic features of the tumor cells with their secretory activities, the clinical history, symptomatology, and biochemical findings. The classification consists of the following eight entities: 1) growth hormone cell adenoma; 2) prolactin cell adenoma; 3) mixed growth hormone cell-prolactin cell adenoma; 4) acidophil stem cell adenoma; 5) corticotroph cell adenoma; 6) thyrotroph cell adenoma; 7) gonadotroph cell adenoma; 8) undifferentiated cell adenoma, including oncocytoma. Prolactin adenomas were found to be the most frequently occurring pituitary adenoma type.
基于对207例从不同年龄、不同临床症状的男性和女性患者手术切除的垂体腺瘤进行组织学、组织化学、免疫细胞学和电子显微镜检查，已制定了一种新的垂体分类法。该分类法主要基于细胞发生学，试图将肿瘤细胞的形态学特征与其分泌活动、临床病史、症状和生化检查结果联系起来。该分类包括以下八个实体：1）生长激素细胞腺瘤；2）催乳素细胞腺瘤；3）生长激素细胞-催乳素细胞混合腺瘤；4）嗜酸性干细胞腺瘤；5）促肾上腺皮质激素细胞腺瘤；6）促甲状腺激素细胞腺瘤；7）促性腺激素细胞腺瘤；8）未分化细胞腺瘤，包括嗜酸性细胞瘤。发现催乳素腺瘤是最常见的垂体腺瘤类型。
