Charpin C, Hassoun J, Oliver C, Jaquet P, Argemi B, Grisoli F, Toga M
Am J Pathol. 1982 Oct;109(1):1-7.
Thirteen pituitary adenomas were removed from patients with Cushing's disease by the transphenoidal route. All cases demonstrated a typical histochemical and ultrastructural pattern. Immunocytochemical study by means of the immunoperoxidase technique and light or electron microscopy demonstrated 1-24/1-39 adrenocorticotropic hormone (ACTH) in all cases, lipotropin/melanotropin (beta-LPH/beta-MSH) in 10 cases, beta-endorphin in 8 cases, and an absence of calcitonin in all cases. In addition, in 2 cases tumor tissue contained a few antiprolactin immunoreactive cells. These ACTH, beta-LPH, and beta-endorphin immunoreactivities may reflect either the peptides themselves or their precursors or intermediate products. The authors also suggest a possible intermediate-lobe-like processing of beta-LPH leading to beta-endorphin production, which may act on PRL cells. In addition, no positive arguments for the existence of a common precursor for calcitonin and ACTH could be provided from this study.
通过经蝶窦途径从库欣病患者身上切除了13个垂体腺瘤。所有病例均呈现出典型的组织化学和超微结构模式。采用免疫过氧化物酶技术并通过光镜或电镜进行的免疫细胞化学研究显示，所有病例中均有促肾上腺皮质激素（ACTH）1 - 24/1 - 39，10例中有促脂素/促黑素（β - LPH/β - MSH），8例中有β - 内啡肽，所有病例中均无降钙素。此外，2例肿瘤组织中含有少量抗催乳素免疫反应性细胞。这些ACTH、β - LPH和β - 内啡肽免疫反应性可能反映了这些肽本身、其前体或中间产物。作者还提出，β - LPH可能存在类似中间叶的加工过程，导致β - 内啡肽产生，这可能作用于催乳素细胞。此外，本研究无法为降钙素和ACTH存在共同前体提供确凿证据。
