挽救与衰老相关的 Dnmt3a2 表达下降可恢复认知能力。
Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities.
机构信息
Department of Neurobiology, Interdisciplinary Centre for Neurosciences, University of Heidelberg, Heidelberg, Germany.
出版信息
Nat Neurosci. 2012 Jul 1;15(8):1111-3. doi: 10.1038/nn.3151.
Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. Moreover, we found that Dnmt3a2 is an activity-regulated immediate early gene that is partly dependent on nuclear calcium signaling and that hippocampal Dnmt3a2 levels determine cognitive abilities in both young adult and aged mice.
认知能力在正常衰老过程中下降，但潜在的分子机制尚不清楚。我们发现衰老与海马体中 DNA 甲基转移酶 Dnmt3a2 的表达减少有关，而恢复 Dnmt3a2 水平则可以恢复认知功能。此外，我们发现 Dnmt3a2 是一种活性调节的即时早期基因，部分依赖于核钙信号，而海马体中的 Dnmt3a2 水平决定了年轻成年和老年小鼠的认知能力。
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