Zheng Xiaoye, Ma Ruixue, He Ershu, Peng Xin, Ma Wenhao, Zhang Xueyan, Li Ying, Li Hanwei, Li Yanjiao, Gong Zhiting
Department of Human Anatomy, Dali University School of Medicine, Dali, China.
Alpha Psychiatry. 2024 Sep 1;25(5):641-647. doi: 10.5152/alphapsychiatry.2024.241602. eCollection 2024 Sep.
Emotional memory has been associated with many psychiatric diseases. Understanding emotional memory could be beneficial in comprehending and discovering new therapies for diseases related to emotional memory, such as depression and post-traumatic stress disorder (PTSD). Our previous study revealed that expression in the dentate gyrus (DG) contributes to fear memory. However, is there a correlation between expression in the DG and reward memory? This study aims to explore the relationship between expression and reward memory.
We induced fear memory (Fear group) or reward memory (Reward group) using fear conditioning and social interaction in females, respectively. We then measured the expression levels of and after the retrieval of different types of memory. Additionally, we used a recombinant Adeno-Associated Virus (rAAV) to overexpress in the DG and conducted conditioned place preference (CPP) tests to assess changes in reward memory.
We observed a significant increase in and expression in the Fear group compared with the Reward group. Overexpression of in the DG led to an increase in time spent in the white box during CPP tests.
expression levels varied after the retrieval of fear or reward memory, and overexpression of in the DG enhanced reward memory. These findings suggest that expression in the DG plays a role in reward memory.
情绪记忆与多种精神疾病相关。了解情绪记忆可能有助于理解和发现针对与情绪记忆相关疾病（如抑郁症和创伤后应激障碍（PTSD））的新疗法。我们之前的研究表明，齿状回（DG）中的[未提及的基因名称]表达有助于恐惧记忆。然而，DG中的[未提及的基因名称]表达与奖赏记忆之间是否存在关联？本研究旨在探讨[未提及的基因名称]表达与奖赏记忆之间的关系。
我们分别使用恐惧条件反射和社交互动在雌性小鼠中诱导恐惧记忆（恐惧组）或奖赏记忆（奖赏组）。然后，在检索不同类型的记忆后，我们测量了[未提及的基因名称]和[未提及的基因名称]的表达水平。此外，我们使用重组腺相关病毒（rAAV）在DG中过表达[未提及的基因名称]，并进行条件性位置偏爱（CPP）测试以评估奖赏记忆的变化。
与奖赏组相比，我们观察到恐惧组中[未提及的基因名称]和[未提及的基因名称]的表达显著增加。在DG中过表达[未提及的基因名称]导致CPP测试期间在白色盒子中花费的时间增加。
在检索恐惧或奖赏记忆后，[未提及的基因名称]表达水平有所变化，并且在DG中过表达[未提及的基因名称]增强了奖赏记忆。这些发现表明，DG中的[未提及的基因名称]表达在奖赏记忆中起作用。
