Research Center for Bioengineering & Sensing Technology, University of Science and Technology Beijing, Beijing 100083, China.
Nanoscale. 2012 Aug 7;4(15):4473-6. doi: 10.1039/c2nr31101a. Epub 2012 Jul 2.
An intelligent photoswitchable single-molecule nanomachine with DNA hairpin-loop structure was designed by the incorporation of azobenzene groups in DNA sequences, which was studied by fluorescence resonance energy transfer (FRET) and attached onto the surface of mesoporous silica. Based on the photo-induced conformational transformation of DNA, highly efficient controlled release was realized.
设计了一种基于 DNA 发夹环结构的智能光致切换型单分子纳米机器，通过将偶氮苯基团引入 DNA 序列中实现，通过荧光共振能量转移（FRET）进行研究，并将其附着在介孔硅表面上。基于 DNA 的光诱导构象转变，实现了高效的控制释放。
