Division of Emergency Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Clin Appl Thromb Hemost. 2012 Nov;18(6):628-32. doi: 10.1177/1076029612451648. Epub 2012 Jun 29.
The generation of thrombin-antithromin (AT) complex (TAT) or soluble fibrin (SF) was prospectively compared with prothrombin fragment 1 + 2 (F1 + 2) generation in patients with disseminated intravascular coagulation (DIC). The plasma levels of TAT, SF, and F1 + 2 were significantly higher in the DIC group than in the non-DIC group. The differences in these levels between the DIC group and non-DIC group were significantly related to infections and hematopoietic tumors. There were no significant differences in the TAT/F1 + 2 ratio between DIC and non-DIC patients, but the SF/F1 + 2 ratio was significantly higher in the DIC group than the non-DIC group. The plasma AT activity was significantly higher in patients with DIC with resolution than in those without resolution, and in survivors than in nonsurvivors. These findings suggest that the ratio of TAT/thrombin is constant between the patients with and without DIC but that the ratio of fibrin formation/thrombin might increase in DIC.
我们前瞻性地比较了弥散性血管内凝血（DIC）患者凝血酶-抗凝血酶（AT）复合物（TAT）或可溶性纤维蛋白（SF）的生成与凝血酶原片段 1 + 2（F1 + 2）的生成。DIC 组患者的 TAT、SF 和 F1 + 2 血浆水平明显高于非 DIC 组。DIC 组和非 DIC 组之间这些水平的差异与感染和造血肿瘤显著相关。DIC 和非 DIC 患者之间的 TAT/F1 + 2 比值无显著差异，但 DIC 组的 SF/F1 + 2 比值明显高于非 DIC 组。与未缓解的 DIC 患者相比，缓解的 DIC 患者的血浆 AT 活性明显升高，与幸存者相比，非幸存者的 AT 活性明显升高。这些发现表明，DIC 患者和非 DIC 患者之间的 TAT/凝血酶比值保持不变，但 DIC 中纤维蛋白形成/凝血酶比值可能增加。
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