Wada H, Takeda Y, Sakakura M, Watanabe R, Nakazaki T, Shiku H, Nishioka J, Nobori T
Second Department of Internal Medicine, Mie University, Tsu 514-8507.
Rinsho Byori. 2001 Aug;49(8):813-7.
Soluble fibrin(SF) is formed in the early-activated state of blood coagulation and quantitative measurement of SF shows high potential as a parameter for the diagnosis of suspected disseminated intravascular coagulation(DIC). The aim of the present study is to evaluate the usefulness of a newly developed SF test utilizing SF specific monoclonal antibody(F405). Among hemopoietic and non-hemopoietic tumor patients, 249 patients with suspected DIC were collected. The SF level showed a good correlation with the DIC score and the SF levels in DIC patients were significantly higher than those in s-DIC and pre-DIC patients. Receiver operating characteristic(ROC) analysis also showed that the specificity and sensitivity of the SF assay were higher than those of thrombin-antithrombin complex(TAT). In conclusion, these results indicate that the SF assay is a highly precise method for the diagnosis and screening of DIC stages.
可溶性纤维蛋白（SF）在凝血早期激活状态下形成，对SF进行定量检测显示出作为疑似弥散性血管内凝血（DIC）诊断参数的巨大潜力。本研究的目的是评估利用SF特异性单克隆抗体（F405）新开发的SF检测方法的实用性。在造血和非造血肿瘤患者中，收集了249例疑似DIC患者。SF水平与DIC评分具有良好的相关性，DIC患者的SF水平显著高于s-DIC和pre-DIC患者。受试者操作特征（ROC）分析还表明，SF检测的特异性和敏感性高于凝血酶 - 抗凝血酶复合物（TAT）。总之，这些结果表明SF检测是一种用于DIC分期诊断和筛查的高度精确的方法。
