Department of Molecular Cell Biology and Centre for Biomedical Genetics, Leiden University Medical Centre, Building 2, Room R-02-022, Postzone S-1-P, PO Box 9600, Einthovenweg 20, 2300 RC, Leiden, The Netherlands.
Cell Mol Life Sci. 2013 Feb;70(3):407-23. doi: 10.1007/s00018-012-1054-x. Epub 2012 Jul 4.
Bone morphogenetic proteins (BMPs) are important extracellular cytokines that play critical roles in embryogenesis and tissue homeostasis. BMPs signal via transmembrane type I and type II serine/threonine kinase receptors and intracellular Smad effector proteins. BMP signaling is precisely regulated and perturbation of BMP signaling is connected to multiple diseases, including musculoskeletal diseases. In this review, we will summarize the recent progress in elucidation of BMP signal transduction, how overactive BMP signaling is involved in the pathogenesis of heterotopic ossification and Duchenne muscular dystrophy, and discuss possible therapeutic strategies for treatment of these diseases.
骨形态发生蛋白（BMPs）是重要的细胞外细胞因子，在胚胎发生和组织动态平衡中发挥关键作用。BMP 通过跨膜 I 型和 II 型丝氨酸/苏氨酸激酶受体和细胞内 Smad 效应蛋白信号转导。BMP 信号转导受到精确调节，BMP 信号转导的扰动与多种疾病有关，包括肌肉骨骼疾病。在这篇综述中，我们将总结阐明 BMP 信号转导的最新进展，过度活跃的 BMP 信号转导如何参与异位骨化和杜氏肌营养不良症的发病机制，并讨论治疗这些疾病的可能治疗策略。
