Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), Research Institute MOVE, VU University and University of Amsterdam, Amsterdam, The Netherlands.
Cytokine Growth Factor Rev. 2012 Feb-Apr;23(1-2):61-7. doi: 10.1016/j.cytogfr.2012.02.001. Epub 2012 Mar 13.
Heterodimeric bone morphogenetic proteins (BMPs) consist of disulfide-linked dimeric monomers derived from different BMP members. Owing to this specific constitution pattern, they bear high affinity to both type I and type II BMP receptors simultaneously. Meanwhile, the antagonism efficiency of extracellular antagonists to heterodimeric BMPs is also significantly lower than that to homodimeric ones. All these specific properties confer heterodimeric BMPs with distinct signaling and bio-functions that are characterized by more speediness, lower concentration/dose threshold and higher efficiency than homodimeric BMPs. Consequently, heterodimeric BMPs bear promising application potential in inducing osteogenesis. In addition, they may play indispensible roles in organogenesis. In this review, we summarize the current knowledge of heterodimeric BMPs in their signaling pathways and bio-functions.
异源二聚体骨形态发生蛋白（BMPs）由不同 BMP 成员衍生的二硫键连接的二聚体单体组成。由于这种特定的组成模式，它们同时具有与 I 型和 II 型 BMP 受体的高亲和力。同时，细胞外拮抗剂对异源二聚体 BMPs 的拮抗效率也明显低于同源二聚体 BMPs。所有这些特定的特性赋予异源二聚体 BMPs 独特的信号转导和生物功能，其特点是比同源二聚体 BMPs 更快、更低的浓度/剂量阈值和更高的效率。因此，异源二聚体 BMPs 在诱导成骨方面具有广阔的应用前景。此外，它们在器官发生中可能发挥不可或缺的作用。本综述总结了异源二聚体 BMPs 在信号通路和生物功能方面的最新知识。
