Weekes M P, Reddi B A J, Wharton S, Gazis A
Department of Infectious Diseases, University of Cambridge Clinical School, UK.
BMJ Case Rep. 2010 Jul 9;2010:bcr0720092113. doi: 10.1136/bcr.07.2009.2113.
We describe a complex case of hyponatraemia with two aetiologies. A 49-year-old man who drank 6 litres of dilute alcohol per day presented confused and oedematous with a serum sodium of 95 mmol/litre. Urine sodium was <10 mmol/litre and urine osmolality 440 mOsmol/kg. Chest x-ray demonstrated a globular heart. ECG showed saddle-shaped ST elevation. ECHO demonstrated a large pericardial effusion causing marked tamponade. Following pericardiocentesis there was a marked diuresis; serum sodium returned to normal after 2 weeks. A full recovery ensued. Cardiac tamponade is associated with antidiuresis via release of antidiuretic hormone (ADH). Tamponade is also associated with antinatriuresis. Antidiuresis and antinatriuresis usually balance in cardiac tamponade; excessive fluid intake may have caused an imbalance in this case.
我们描述了一例病因复杂的低钠血症病例。一名49岁男性,每天饮用6升稀释酒精,出现意识模糊和水肿,血清钠为95毫摩尔/升。尿钠<10毫摩尔/升,尿渗透压440毫摩尔/千克。胸部X线显示心脏呈球形。心电图显示鞍形ST段抬高。超声心动图显示大量心包积液导致明显心包填塞。心包穿刺术后出现明显利尿;2周后血清钠恢复正常。随后完全康复。心包填塞通过抗利尿激素(ADH)释放与抗利尿相关。心包填塞也与钠排泄减少相关。在心包填塞中,抗利尿和钠排泄减少通常相互平衡;过量饮水可能导致了本例中的失衡。