Liu Y C, Zhu P J, Li Z Y, Yu D Z
Department of Physiology, Zhejiang Medical University, Hangzhou, China.
Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):526-8.
The effects of bretylium tosylate (BT) on the electrophysiologic properties of normal and digitalized papillary muscles isolated from guinea pigs were studied with regular glass microelectrode. BT prolonged effective refractory period (ERP) and action potential duration (APD) of normal papillary muscles. The ERP and APD of papillary muscles were shortened by perfusion with ouabain (Oua) 0.2 mumol.L-1. No recovery was seen in perfusion without drug for 30 min. In digitalized papillary muscles with Oua, ERP, APD90, and APD50 were prolonged by BT 120 mumol.L-1 form 175 +/- 20, 187 +/- 20, and 146 +/- 21 ms to 222 +/- 21, 220 +/- 19, and 190 +/- 19 ms, respectively. The results demonstrated that BT can prolong ERP and APD of papillary muscles digitalized with Oua.
用常规玻璃微电极研究了甲苯磺酸溴苄铵（BT）对从豚鼠分离的正常和洋地黄化乳头肌电生理特性的影响。BT可延长正常乳头肌的有效不应期（ERP）和动作电位时程（APD）。用0.2μmol·L-1哇巴因（Oua）灌注可缩短乳头肌的ERP和APD。在无药物灌注30分钟的情况下未见恢复。在使用Oua的洋地黄化乳头肌中，120μmol·L-1的BT可使ERP、APD90和APD50分别从175±20、187±20和146±21毫秒延长至222±21、220±19和190±19毫秒。结果表明，BT可延长用Oua洋地黄化的乳头肌的ERP和APD。
