Zhang S T, Li X G, Liu C H
Research Laboratory of Electrophysiology, Xi-an Medical University, China.
Zhongguo Yao Li Xue Bao. 1990 Mar;11(2):166-8.
The effects of copper chloride (CuCl2) on action potentials and contractile forces of guinea pig papillary muscles and cultured myocardial cells from neonatal rats were studied by means of an intracellular microelectrode and transducers. The results showed CuCl2 50 mumol/L reduced action potential amplitude (APA) and maximal depolarization rate of 0 phase (Vmax), shortened action potential duration at 50% (APD50) and at 90% (APD90) repolarization, prolonged effective refractory period (ERP), inhibited contractile force of guinea pig papillary muscles. The effect of CuCl2 on AP of cultured myocardial cells was similar to those of guinea pig papillary muscles. The beating rate and contractile amplitude of cultured myocardial cells were decreased by CuCl2 50 mumol/L from 102 +/- 44 bpm to 58 +/- 21 bpm and from 100% to 69 +/- 17% respectively. These suggest that CuCl2 may be an anti-arrhythmic element.
采用细胞内微电极和换能器的方法，研究了氯化铜（CuCl₂）对豚鼠乳头肌及新生大鼠培养心肌细胞动作电位和收缩力的影响。结果显示，50 μmol/L的CuCl₂降低了动作电位幅度（APA）和0期最大去极化速率（Vmax），缩短了复极化50%（APD50）和90%（APD90）时的动作电位时程，延长了有效不应期（ERP），抑制了豚鼠乳头肌的收缩力。CuCl₂对培养心肌细胞动作电位的影响与豚鼠乳头肌相似。50 μmol/L的CuCl₂使培养心肌细胞的搏动频率和收缩幅度分别从102±44次/分钟降至58±21次/分钟，从100%降至69±17%。这些结果提示，CuCl₂可能是一种抗心律失常物质。
