Mujawar Shahid A, Patil Vinayak W, Daver Rekha G
Indian J Clin Biochem. 2011 Jul;26(3):257-60. doi: 10.1007/s12291-011-0109-3. Epub 2011 Jan 19.
The present study was carried out to evaluate the occurrence of association between homocysteine, folic acid and vitamin B(12) in patients with preeclampsia. Fifty preeclamptic patients from gynecology ward were studied for estimation of serum homocysteine, folic acid and vitamin B(12) over a period of October 2007 to June 2010. Serum homocysteine and folic acid, and vitamin B(12) were determined by means of Immulite 1000 analyzer. The statistical analysis of study group of preeclampsia compared with normotensive control group, showed significant alterations in serum homocysteine, folic acid and vitamin B(12) concentrations in preeclampsia. Inverse association between serum homocysteine and folic acid, and vitamin B(12) levels were observed in preeclampsia. The present study found hyperhomocysteinemia and deficiency of folic acid and vitamin B(12) along with increased blood pressure as a risk factor for cardiovascular disease (CVD) in preeclampsia.
本研究旨在评估子痫前期患者同型半胱氨酸、叶酸和维生素B12之间的关联情况。2007年10月至2010年6月期间，对妇科病房的50例子痫前期患者进行了血清同型半胱氨酸、叶酸和维生素B12的测定。血清同型半胱氨酸、叶酸和维生素B12通过免疫比浊法1000分析仪测定。与血压正常的对照组相比，子痫前期研究组的统计分析显示，子痫前期患者血清同型半胱氨酸、叶酸和维生素B12浓度有显著变化。子痫前期患者血清同型半胱氨酸与叶酸及维生素B12水平呈负相关。本研究发现，高同型半胱氨酸血症、叶酸和维生素B12缺乏以及血压升高是子痫前期患者心血管疾病（CVD）的危险因素。
