子痫前期患者血清同型半胱氨酸、叶酸和维生素B12的研究。
Study of serum homocysteine, folic Acid and vitamin b(12) in patients with preeclampsia.
作者信息
Mujawar Shahid A, Patil Vinayak W, Daver Rekha G
出版信息
Indian J Clin Biochem. 2011 Jul;26(3):257-60. doi: 10.1007/s12291-011-0109-3. Epub 2011 Jan 19.
Abstract
The present study was carried out to evaluate the occurrence of association between homocysteine, folic acid and vitamin B(12) in patients with preeclampsia. Fifty preeclamptic patients from gynecology ward were studied for estimation of serum homocysteine, folic acid and vitamin B(12) over a period of October 2007 to June 2010. Serum homocysteine and folic acid, and vitamin B(12) were determined by means of Immulite 1000 analyzer. The statistical analysis of study group of preeclampsia compared with normotensive control group, showed significant alterations in serum homocysteine, folic acid and vitamin B(12) concentrations in preeclampsia. Inverse association between serum homocysteine and folic acid, and vitamin B(12) levels were observed in preeclampsia. The present study found hyperhomocysteinemia and deficiency of folic acid and vitamin B(12) along with increased blood pressure as a risk factor for cardiovascular disease (CVD) in preeclampsia.
摘要
本研究旨在评估子痫前期患者同型半胱氨酸、叶酸和维生素B12之间的关联情况。2007年10月至2010年6月期间，对妇科病房的50例子痫前期患者进行了血清同型半胱氨酸、叶酸和维生素B12的测定。血清同型半胱氨酸、叶酸和维生素B12通过免疫比浊法1000分析仪测定。与血压正常的对照组相比，子痫前期研究组的统计分析显示，子痫前期患者血清同型半胱氨酸、叶酸和维生素B12浓度有显著变化。子痫前期患者血清同型半胱氨酸与叶酸及维生素B12水平呈负相关。本研究发现，高同型半胱氨酸血症、叶酸和维生素B12缺乏以及血压升高是子痫前期患者心血管疾病（CVD）的危险因素。
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本文引用的文献
1
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Atherosclerosis. 2005 Apr;179(2):285-92. doi: 10.1016/j.atherosclerosis.2004.10.026. Epub 2004 Dec 15.
2
Mapping the theories of preeclampsia: the role of homocysteine.子痫前期理论解析：同型半胱氨酸的作用
Obstet Gynecol. 2005 Feb;105(2):411-25. doi: 10.1097/01.AOG.0000151117.52952.b6.
3
Methionine metabolism in mammals.哺乳动物中的蛋氨酸代谢。
J Nutr Biochem. 1990 May;1(5):228-37. doi: 10.1016/0955-2863(90)90070-2.
4
Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis.同型半胱氨酸与心血管疾病：一项荟萃分析得出的因果关系证据
BMJ. 2002 Nov 23;325(7374):1202. doi: 10.1136/bmj.325.7374.1202.
5
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.亚甲基四氢叶酸还原酶677C→T多态性与冠心病风险：一项荟萃分析
JAMA. 2002;288(16):2023-31. doi: 10.1001/jama.288.16.2023.
6
Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study.低膳食叶酸摄入量与急性冠脉事件的高发率相关：库奥皮奥缺血性心脏病危险因素研究。
Circulation. 2001 Jun 5;103(22):2674-80. doi: 10.1161/01.cir.103.22.2674.
7
Mutations in the gene for methylenetetrahydrofolate reductase, homocysteine levels, and vitamin status in women with a history of preeclampsia.有先兆子痫病史女性的亚甲基四氢叶酸还原酶基因中的突变、同型半胱氨酸水平及维生素状态
Am J Obstet Gynecol. 2001 Feb;184(3):394-402. doi: 10.1067/mob.2001.109393.
8
Second-trimester plasma homocysteine levels and pregnancy-induced hypertension, preeclampsia, and intrauterine growth restriction.孕中期血浆同型半胱氨酸水平与妊娠高血压、先兆子痫及胎儿生长受限
Am J Obstet Gynecol. 2000 Oct;183(4):805-9. doi: 10.1067/mob.2000.109044.
9
Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study.血浆总同型半胱氨酸、妊娠并发症及不良妊娠结局：霍达兰同型半胱氨酸研究
Am J Clin Nutr. 2000 Apr;71(4):962-8. doi: 10.1093/ajcn/71.4.962.
10
Changes in homocysteine levels during normal pregnancy.
Am J Obstet Gynecol. 1999 Mar;180(3 Pt 1):660-4. doi: 10.1016/s0002-9378(99)70269-3.
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