Adinortey Michael B, Gyan Ben E, Adjimani Jonathan, Nyarko Philomena, Sarpong Charity, Tsikata Francis Y, Nyarko Alexander K
Indian J Clin Biochem. 2011 Jul;26(3):261-8. doi: 10.1007/s12291-010-0101-3. Epub 2011 Jan 12.
In this study, differences in lipid levels amongst diabetics with and without complications were assessed to determine lipid disorders that are associated with diabetic complications other than cardiovascular diseases. A Cross sectional study design was employed. The study included 288 diabetics and 108 non diabetics with different types of complications such as hypertension, nephropathy, neuropathy, and retinopathy. The mean serum total cholesterol was higher in patients with complications compared to those without complications and the non-diabetic controls. The normotensive diabetic patients had the lowest total cholesterol among the diabetic patients' groups (4.65 ± 0.17 mmol/l) compared to the diabetics with hypertension (6.051 ± 0.20 mmol/l), retinopathy (6.26 ± 0.29 mmol/l), neuropathy (5.80 ± 0.17 mmol/l) and nephropathy patients 5.74 ± 0.26 mmol/l (P < 0.05). The prevalence of dyslipidaemia among diabetic subjects was between 19.2 and 84.0%. The study shows that, in addition to macrovascular complications, dyslipidaemia is common in type 2 diabetes mellitus patients with microvascular complications.
在本研究中，评估了有并发症和无并发症的糖尿病患者的血脂水平差异，以确定与心血管疾病以外的糖尿病并发症相关的脂质紊乱。采用横断面研究设计。该研究纳入了288名糖尿病患者和108名非糖尿病患者，他们患有不同类型的并发症，如高血压、肾病、神经病变和视网膜病变。与无并发症的患者和非糖尿病对照组相比，有并发症的患者血清总胆固醇均值更高。与患有高血压（6.051±0.20 mmol/l）、视网膜病变（6.26±0.29 mmol/l）、神经病变（5.80±0.17 mmol/l）和肾病（5.74±0.26 mmol/l）的糖尿病患者相比，血压正常的糖尿病患者在糖尿病患者组中总胆固醇最低（4.65±0.17 mmol/l）（P<0.05）。糖尿病患者中血脂异常的患病率在19.2%至84.0%之间。该研究表明，除大血管并发症外，血脂异常在患有微血管并发症的2型糖尿病患者中也很常见。
