Eghan Benjamin A, Acheampong Joseph W
Department of Medicine, Kwame Nkrumah University of Science and Technology, School of Medical Sciences, Kumasi, Ghana.
Croat Med J. 2003 Oct;44(5):576-8.
To determine the prevalence of dyslipidemia among hospital patients in Kumasi, Ghana, whose diet consists mostly of carbohydrates and little proteins, and assess the effect of age, sex, and the presence of hypertension and diabetes mellitus on serum cholesterol concentration.
The hospital-based study included 248 patients (145 women and 103 men) selected by strict random sampling from patients visiting Komfo Anokye Teaching Hospital between May 1, 1999, and April 30, 2000. The patients were divided into four groups: patients with hypertension, diabetes mellitus, both conditions, and without either disease. We measured lipid concentration in the serum of patients and assessed its correlation with age, sex, body mass index, and the presence or absence of diabetes mellitus or hypertension.
Almost half of the patients (45%) had serum total cholesterol concentration >5.17 mmol/L and 26% had also serum triglyceride concentration >1.69 mmol/L. High-density lipoprotein (HDL)-cholesterol dyslipidemia (HDL< 1.03 mmol/L) was found in 30.5% of the patients, and low-density lipoprotein (LDL)-cholesterol dyslipidemia (LDL>2.58 mmol/L) in 72%. Serum total cholesterol concentration was significantly high in the patients with hypertension alone (p=0.01). LDL-cholesterol and serum triglyceride concentrations appeared higher in those who had both hypertension and diabetes, but this was not statistically significant. Serum HDL-cholesterol was higher in the group with diabetes alone but also failed to achieve statistical significance.
Dyslipidemia is common in patients visiting hospital in Kumasi, although the regular diet is based on carbohydrates and poor in fat. Steps are needed to curb lipid-related disorders.
确定在加纳库马西的医院患者中血脂异常的患病率，这些患者的饮食主要由碳水化合物组成且蛋白质含量少，并评估年龄、性别以及高血压和糖尿病的存在对血清胆固醇浓度的影响。
这项基于医院的研究纳入了248名患者（145名女性和103名男性），这些患者是在1999年5月1日至2000年4月30日期间从访问Komfo Anokye教学医院的患者中通过严格随机抽样选取的。患者被分为四组：患有高血压、糖尿病、两种疾病都有的患者以及两种疾病都没有的患者。我们测量了患者血清中的脂质浓度，并评估了其与年龄、性别、体重指数以及糖尿病或高血压的存在与否之间的相关性。
几乎一半的患者（45%）血清总胆固醇浓度>5.17 mmol/L，26%的患者血清甘油三酯浓度也>1.69 mmol/L。30.5%的患者存在高密度脂蛋白（HDL）-胆固醇血脂异常（HDL<1.03 mmol/L），72%的患者存在低密度脂蛋白（LDL）-胆固醇血脂异常（LDL>2.58 mmol/L）。仅患有高血压的患者血清总胆固醇浓度显著升高（p=0.01）。同时患有高血压和糖尿病的患者的LDL-胆固醇和血清甘油三酯浓度似乎更高，但这在统计学上不显著。仅患有糖尿病的组中血清HDL-胆固醇更高，但也未达到统计学显著性。
在库马西就诊的患者中血脂异常很常见，尽管常规饮食以碳水化合物为主且脂肪含量低。需要采取措施控制与脂质相关的疾病。
