间充质干细胞归巢之旅：增强干细胞治疗功效和安全性的策略。
Journey of mesenchymal stem cells for homing: strategies to enhance efficacy and safety of stem cell therapy.
机构信息
Stem Cell Research Center, RNL BIO, Gasan-Dong, Geumcheon-Gu, Seoul 153-768, Republic of Korea.
出版信息
Stem Cells Int. 2012;2012:342968. doi: 10.1155/2012/342968. Epub 2012 Jun 13.
Abstract
Human mesenchymal stem cells (MSCs) communicate with other cells in the human body and appear to "home" to areas of injury in response to signals of cellular damage, known as homing signals. This review of the state of current research on homing of MSCs suggests that favorable cellular conditions and the in vivo environment facilitate and are required for the migration of MSCs to the site of insult or injury in vivo. We review the current understanding of MSC migration and discuss strategies for enhancing both the environmental and cellular conditions that give rise to effective homing of MSCs. This may allow MSCs to quickly find and migrate to injured tissues, where they may best exert clinical benefits resulting from improved homing and the presence of increased numbers of MSCs.
摘要
人类间充质干细胞（MSCs）与人体内的其他细胞进行交流，并在接收到细胞损伤的信号（称为归巢信号）时，似乎会“归巢”到损伤区域。这篇关于 MSCs 归巢状态的研究综述表明，有利的细胞条件和体内环境有利于并需要 MSC 向体内损伤或伤害部位迁移。我们综述了目前对 MSC 迁移的理解，并讨论了增强环境和细胞条件的策略，这些策略可以促进 MSC 的有效归巢。这可能使 MSCs 能够快速找到并迁移到受伤组织，在那里它们可能会从改善的归巢和增加的 MSC 数量带来的临床益处中获益最大。
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