Das Pratik, Pal Debajyoti, Roy Sudipta, Chaudhuri Shubhamitra, Kesh Shyam S, Basak Piyali, Nandi Samit K
Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences.
School of Bioscience and Engineering, Jadavpur University.
Int J Surg. 2024 Oct 1;110(10):6382-6401. doi: 10.1097/JS9.0000000000001812.
This comprehensive review explores the complex terrain of stem cell therapies as a potential therapeutic frontier in the healing of complicated burn wounds. Serious tissue damage, impaired healing processes, and possible long-term consequences make burn wounds a complex problem. An in-depth review is required since, despite medical progress, existing methods for treating severe burn wounds have significant limitations. Burn wounds are difficult to heal because they cause extensive tissue damage. The challenges of burn injury-induced tissue regeneration and functional recovery are also the subject of this review. Although there is a lot of promise in current stem cell treatments, there are also some limitations with scalability, finding the best way to transport the cells, and finding consistent results across different types of patients. To shed light on how to improve stem cell interventions to heal severe burn wounds, this review covers various stem cell applications in burn wounds and examines these obstacles. To overcome these obstacles, one solution is to enhance methods of stem cell distribution, modify therapies according to the severity of the burn, and conduct more studies on how stem cell therapy affects individual patients. Novel solutions may also be possible through the combination of cutting-edge technologies like nanotechnology and biotechnology. This review seeks to increase stem cell interventions by analyzing present challenges and suggesting strategic improvements. The goal is to provide a more effective and tailored way to repair serious burn wounds.
这篇全面的综述探讨了干细胞疗法这一复杂领域，它是复杂烧伤创面愈合中一个潜在的治疗前沿。严重的组织损伤、受损的愈合过程以及可能的长期后果使烧伤创面成为一个复杂的问题。尽管医学取得了进展，但现有治疗严重烧伤创面的方法仍有显著局限性，因此需要进行深入综述。烧伤创面因造成广泛组织损伤而难以愈合。烧伤损伤引起的组织再生和功能恢复的挑战也是本综述的主题。虽然当前干细胞治疗有很大前景，但在可扩展性、找到最佳细胞运输方式以及在不同类型患者中获得一致结果方面也存在一些局限性。为阐明如何改进干细胞干预措施以治愈严重烧伤创面，本综述涵盖了干细胞在烧伤创面的各种应用，并审视了这些障碍。为克服这些障碍，一种解决方案是改进干细胞分布方法，根据烧伤严重程度调整治疗方案，并对干细胞疗法如何影响个体患者进行更多研究。通过纳米技术和生物技术等前沿技术的结合，也可能找到新的解决方案。本综述旨在通过分析当前挑战并提出策略性改进措施来增加干细胞干预。目标是提供一种更有效、更具针对性的方法来修复严重烧伤创面。
