Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, BC, Canada V8W 2Y2.
Stem Cells Int. 2012;2012:454180. doi: 10.1155/2012/454180. Epub 2012 Jun 13.
The birth of new neurons from unspecialized neural stem and progenitor cells surrounding the lateral ventricles occurs throughout postnatal life. This process, termed neurogenesis, is complex and multistepped, encompassing several types of cellular behaviours, such as proliferation, differentiation, and migration. These behaviours are influenced by numerous factors present in the unique, permissive microenvironment. A major cellular mechanism for sensing the plethora of environmental cues directing this process is the presence of different channel forming proteins spanning the plasma membrane. So-called large pore membrane channels, which are selective for the passage of specific types of small molecules and ions, are emerging as an important subgroup of channel proteins. Here, we focus on the roles of three such large pore channels, aquaporin 4, connexin 43, and pannexin 1. We highlight both their independent functions as well as the accumulating evidence for crosstalk between them.
新神经元从侧脑室周围未特化的神经干细胞和祖细胞中产生，这一过程发生在整个出生后生命过程中。这个过程被称为神经发生，是复杂的多步骤过程，包括几种类型的细胞行为，如增殖、分化和迁移。这些行为受到存在于独特的、允许的微环境中的许多因素的影响。一种主要的细胞机制是通过跨越质膜的不同通道形成蛋白来感知指导这个过程的大量环境线索。所谓的大孔膜通道选择性地允许特定类型的小分子和离子通过，它们正在成为通道蛋白的一个重要亚群。在这里，我们重点介绍三种这样的大孔通道，水通道蛋白 4、连接蛋白 43 和连接蛋白 1。我们强调了它们作为独立功能的作用，以及它们之间相互作用的证据积累。
