猪繁殖与呼吸综合征病毒在其自然宿主细胞中通过转录后调控诱导 I 型干扰素。
Post-transcriptional control of type I interferon induction by porcine reproductive and respiratory syndrome virus in its natural host cells.
机构信息
Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA.
出版信息
Viruses. 2012 May;4(5):725-33. doi: 10.3390/v4050725. Epub 2012 May 2.
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is not only a poor inducer of type I interferon but also inhibits the efficient induction of type I interferon by porcine transmissible gastroenteritis virus (TGEV) and synthetic dsRNA molecules, Poly I:C. However, the mechanistic basis by which PRRSV interferes with the induction of type I interferon in its natural host cells remains less well defined. The purposes of this review are to summarize the key findings in supporting the post-transcriptional control of type I interferon in its natural host cells and to propose the possible role of translational control in the regulation of type I interferon induction by PRRSV.
摘要
猪繁殖与呼吸综合征病毒（PRRSV）不仅是Ⅰ型干扰素的弱诱导剂，还能抑制猪传染性胃肠炎病毒（TGEV）和聚肌胞（Poly I:C）等合成 dsRNA 分子诱导Ⅰ型干扰素的有效产生。然而，PRRSV 在其自然宿主细胞中干扰Ⅰ型干扰素产生的机制基础仍不明确。本综述旨在总结支持Ⅰ型干扰素在其自然宿主细胞中转录后调控的关键发现，并提出 PRRSV 调控Ⅰ型干扰素诱导的翻译调控可能作用。
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