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骨膜蛋白在变应性鼻炎小鼠模型中的症状表现和气道重塑中的作用。

Roles of periostin in symptom manifestation and airway remodeling in a murine model of allergic rhinitis.

机构信息

Department of Otorhinolaryngology, School of Medicine, Gyeongsang National University, Jinju, Korea.

出版信息

Allergy Asthma Immunol Res. 2012 Jul;4(4):222-30. doi: 10.4168/aair.2012.4.4.222. Epub 2012 Jun 8.

DOI:10.4168/aair.2012.4.4.222
PMID:22754716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3378929/
Abstract

PURPOSE

Periostin was originally identified as a secreted factor during screening of a mouse osteoblastic library. In a recent study, periostin was found to directly regulate eosinophil accumulation in allergic mucosal inflammation. Chronic eosinophilic inflammation is related to the development of remodeling. The present study examined the expression of periostin and evaluated its role in the inflammatory process and remodeling associated with allergic rhinitis.

METHODS

A murine model of allergic rhinitis was established in periostin knockout mice. We analyzed the expression of periostin, manifestation of nasal symptoms, eosinophilic inflammation, and subepithelial fibrosis as well as the expression of MMP-2, TIMP-1, and type 1 collagen in nasal tissue.

RESULTS

Periostin was mainly distributed in the subepithelial tissue of the nasal mucosa. The subepithelial tissue was thinner in the knockout group than in the control group. No differences in the expression of MMP-2 or TIMP-1 were found in the knockout group. However, after a month of allergen challenge, type I collagen in the nasal tissue was lower in the knockout group than in the control group. The number of eosinophils and the symptom score were also lower in the knockout group.

CONCLUSIONS

Periostin is expressed in nasal tissues of murine models of allergic rhinitis. Periostin deficiency may affect the remodeling of nasal tissue with reduced subepithelial fibrosis, and lead to less eosinophilic inflammation.

摘要

目的

骨膜蛋白最初是在筛选小鼠成骨细胞文库时被鉴定为一种分泌因子。在最近的一项研究中，发现骨膜蛋白可直接调节变应性黏膜炎症中的嗜酸性粒细胞聚集。慢性嗜酸性粒细胞炎症与重塑的发展有关。本研究检测了骨膜蛋白的表达，并评估了其在变应性鼻炎相关炎症过程和重塑中的作用。

方法

在骨膜蛋白敲除小鼠中建立变应性鼻炎的小鼠模型。我们分析了骨膜蛋白的表达、鼻部症状的表现、嗜酸性粒细胞炎症和上皮下纤维化以及鼻组织中 MMP-2、TIMP-1 和 I 型胶原的表达。

结果

骨膜蛋白主要分布在鼻黏膜的上皮下组织中。敲除组的上皮下组织比对照组薄。敲除组 MMP-2 或 TIMP-1 的表达无差异。然而，在过敏原攻击一个月后，敲除组鼻组织中的 I 型胶原低于对照组。嗜酸性粒细胞的数量和症状评分也在敲除组中较低。

结论

骨膜蛋白在变应性鼻炎小鼠模型的鼻组织中表达。骨膜蛋白缺失可能会影响鼻组织的重塑，减少上皮下纤维化，并导致嗜酸性粒细胞炎症减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/818b/3378929/7f07897ebfd3/aair-4-222-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/818b/3378929/15d4b34b5d64/aair-4-222-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/818b/3378929/4cb2acc7e0e7/aair-4-222-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/818b/3378929/241ff5e695f4/aair-4-222-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/818b/3378929/1f1500d80c67/aair-4-222-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/818b/3378929/7f07897ebfd3/aair-4-222-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/818b/3378929/7f07897ebfd3/aair-4-222-g008.jpg

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J Immunol. 2011 Apr 15;186(8):4959-66. doi: 10.4049/jimmunol.1002359. Epub 2011 Mar 14.
2
Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma.上皮细胞衍生的骨膜蛋白在哮喘中 TGF-β激活、胶原产生和胶原凝胶弹性中的作用。
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14170-5. doi: 10.1073/pnas.1009426107. Epub 2010 Jul 26.
3
Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses.
Cells. 2022 Dec 22;12(1):50. doi: 10.3390/cells12010050.
4
Evaluation of Neo-Osteogenesis in Eosinophilic Chronic Rhinosinusitis Using a Nasal Polyp Murine Model.使用鼻息肉小鼠模型评估嗜酸性慢性鼻-鼻窦炎中的新骨形成
Allergy Asthma Immunol Res. 2020 Mar;12(2):306-321. doi: 10.4168/aair.2020.12.2.306.
5
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Clin Exp Allergy. 2017 Oct;47(10):1263-1274. doi: 10.1111/cea.12934. Epub 2017 May 5.
6
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Crit Rev Biochem Mol Biol. 2015;50(5):427-39. doi: 10.3109/10409238.2015.1069791. Epub 2015 Aug 10.
7
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J Allergy Clin Immunol. 2014 Dec;134(6):1433-1442. doi: 10.1016/j.jaci.2014.05.029. Epub 2014 Jul 2.
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J Invest Dermatol. 2014 Aug;134(8):2105-2113. doi: 10.1038/jid.2014.120. Epub 2014 Feb 27.
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Dev Biol. 2007 Feb 1;302(1):256-66. doi: 10.1016/j.ydbio.2006.09.048. Epub 2006 Oct 4.
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J Allergy Clin Immunol. 2006 Jul;118(1):98-104. doi: 10.1016/j.jaci.2006.02.046. Epub 2006 Apr 27.