癌症免疫反应的遗传推断。
A genetic inference on cancer immune responsiveness.
机构信息
Infectious Disease and Immunogenetics Section (IDIS); Department of Transfusion Medicine; Clinical Center and trans-NIH Center for Human Immunology (CHI); National Institutes of Health; Bethesda, MD USA.
出版信息
Oncoimmunology. 2012 Jul 1;1(4):520-525. doi: 10.4161/onci.19531.
Abstract
A cancer immune signature implicating good prognosis and responsiveness to immunotherapy was described that is observed also in other aspects of immune-mediated, tissue-specific destruction (TSD). Its determinism remains, however, elusive. Based on limited but unique clinical observations, we propose a multifactorial genetic model of human cancer immune responsiveness.
摘要
一个癌症免疫特征被描述为预后良好且对免疫疗法有反应，这在其他免疫介导的组织特异性破坏（TSD）方面也观察到。然而，其确定性仍然难以捉摸。基于有限但独特的临床观察，我们提出了一个人类癌症免疫反应的多因素遗传模型。
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