Division of Experimental Pathology; Institute of Pathology; University of Bern; Bern, Switzerland.
Oncoimmunology. 2012 Jul 1;1(4):529-530. doi: 10.4161/onci.19459.
Expression or release of immunosuppressive molecules may protect tumor cells from the recognition and destruction by the immune system. New findings indicate that colorectal tumors produce immunoregulatory glucocorticoids and thereby suppress immune cell activation. The nuclear receptor LRH-1 plays a critical role in the regulation of colorectal tumor proliferation and glucocorticoid synthesis.
免疫抑制分子的表达或释放可能保护肿瘤细胞免受免疫系统的识别和破坏。新的发现表明，结直肠肿瘤产生免疫调节糖皮质激素，从而抑制免疫细胞的激活。核受体 LRH-1 在结直肠肿瘤增殖和糖皮质激素合成的调控中发挥着关键作用。
