白细胞介素 21 损害结肠炎相关结直肠癌的肿瘤免疫监视。
Interleukin 21 impairs tumor immunosurveillance of colitis-associated colorectal cancer.
机构信息
Laboratory of Chronic Immunopathology; Department of Surgery; University Medical Center Regensburg; Regensburg, Germany.
出版信息
Oncoimmunology. 2012 Jul 1;1(4):537-538. doi: 10.4161/onci.19407.
Abstract
The pathogenesis of colitis-associated colorectal cancer is strongly influenced by immune cells, cytokines and other immune mediators present in the inflamed colon. Current research has emerged that T helper cell associated cytokines play a prominent role in tumor growth. In our recent manuscript we have revealed that the Th17 associated cytokine IL-21 prominently influences tumor development and immunosurveillance of colitis-associated colorectal cancer.
摘要
结肠炎相关结直肠癌的发病机制受到炎症结肠中存在的免疫细胞、细胞因子和其他免疫介质的强烈影响。目前的研究表明，辅助性 T 细胞相关细胞因子在肿瘤生长中起着突出的作用。在我们最近的论文中，我们揭示了 Th17 相关细胞因子 IL-21 显著影响结肠炎相关结直肠癌的肿瘤发展和免疫监视。
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