Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, BBRB 446; Box 23, Birmingham, AL 35294-2170, USA.
Microbes Infect. 2010 Dec;12(14-15):1111-9. doi: 10.1016/j.micinf.2010.08.008. Epub 2010 Sep 9.
Interleukin-21 (IL-21) is a cytokine that has broad effects on both innate and adaptive immune responses. The roles of IL-21 in determining immunity to infections are currently being defined, and notably, it has been shown that IL-21 is most critical for sustaining T cell responses during chronic viral infections. This article discusses our current understanding of the immunobiology of IL-21, as well as its known and potential roles in influencing immunity to infections.
白细胞介素-21（IL-21）是一种细胞因子，对先天和适应性免疫反应都有广泛的影响。IL-21 在决定对感染的免疫中的作用目前正在确定，值得注意的是，已经表明 IL-21 在慢性病毒感染期间维持 T 细胞反应中最为关键。本文讨论了我们目前对 IL-21 的免疫生物学的理解，以及其在影响感染免疫方面的已知和潜在作用。
