CyberKnife 肿瘤追踪技术：治疗高危手术患者单发肺外周转移的有效方法。
CyberKnife with Tumor Tracking: An Effective Treatment for High-Risk Surgical Patients with Single Peripheral Lung Metastases.
机构信息
Department of Radiation Medicine, Georgetown University Hospital Washington, DC, USA.
出版信息
Front Oncol. 2012 Jun 29;2:63. doi: 10.3389/fonc.2012.00063. eCollection 2012.
Standard treatment for operable patients with single peripheral lung metastases is metastasectomy. We report mature CyberKnife outcomes for high-risk surgical patients with biopsy proven single peripheral lung metastases. Twenty-four patients (median age 73 years) with a mean maximum tumor diameter of 2.5 cm (range, 0.8-4.5 cm) were treated over a 6-year period extending from September 2004 to September 2010 and followed for a minimum of 1 year or until death. A mean dose of 52 Gy (range, 45-60 Gy) was delivered to the prescription isodose line in three fractions over a 3-11 day period (mean, 7 days). At a median follow-up of 20 months, the 2-year Kaplan-Meier local control and overall survival rates were 87 and 50%, respectively. CyberKnife with fiducial tracking is an effective treatment for high-risk surgical patients with single small peripheral lung metastases. Trials comparing CyberKnife with metastasectomy for operable patients are necessary to confirm equivalence.
对于可手术的单发周围性肺转移患者，标准治疗方法是转移灶切除术。我们报告了经活检证实为单发周围性肺转移的高危手术患者接受 CyberKnife 治疗的成熟结果。24 例患者（中位年龄 73 岁），最大肿瘤直径平均为 2.5cm（范围，0.8-4.5cm），在 2004 年 9 月至 2010 年 9 月的 6 年期间接受治疗，随访时间至少 1 年或直至死亡。在 3-11 天（平均 7 天）的时间内，以 3 个分次给予平均剂量为 52Gy（范围，45-60Gy），达到处方等剂量线。中位随访 20 个月时，2 年的 Kaplan-Meier 局部控制率和总生存率分别为 87%和 50%。带有基准点跟踪的 CyberKnife 是治疗单发小周围性肺转移高危手术患者的有效方法。需要进行比较 CyberKnife 与转移灶切除术治疗可手术患者的临床试验，以确认其等效性。
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