银屑病蒙罗微脓肿、角质层和血管中的免疫反应性。

Immune reactivity in psoriatic munro-saboureau microabscesses, stratum corneum and blood vessels.

作者信息

Abreu-Velez Ana Maria, Googe Paul B, Howard Michael S

机构信息

Georgia Dermatopathology Associates, Atlanta, Georgia, USA.

出版信息

N Am J Med Sci. 2012 Jun;4(6):257-65. doi: 10.4103/1947-2714.97204.

DOI:10.4103/1947-2714.97204

PMID:22754876

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3385361/

Abstract

BACKGROUND

A characteristic feature of early active psoriatic lesions is the intraepidermal penetration of neutrophils, with attendant formation of Munro-Saboureau microabscesses. Previous immunofluorescence studies have shown reactivity of in vivo binding of stratum corneum antibodies (SCAs) within the Munro-Saboreau microabscesses in cases of psoriasis.

AIMS

In our study, we aimed to investigate any correlation between the SCAs and the Munro-Saboureau microabscesses.

MATERIALS AND METHODS

We investigated 50 archival biopsies of psoriasis with Munro-Saboureau microabscesses, and attempted to confirm antibody colocalization within these microabcesses via immunohistochemistry staining. As controls, we utilized 50 skin biopsies from healthy patients undergoing esthetic plastic surgery procedures.

RESULTS

Within the Munro-Saboureau microabscesses, the following markers were statistically significantly positive relative to controls: CD1a, CD8, CD23, cyclooxygenase-2, myeloid histoid antigen, albumin, fibrinogen, kappa, lambda, von Willebrand factor, IgG, IgM, IgD, complement/C3c, C3d, myeloperoxidase, and carcinoembryonic antigen (P < 0.05). Autoreactivity to blood vessels was also detected, with multiple immunoglobulins and complement factors.

CONCLUSIONS

We document important correlations between the Munro-Saboureau microabscesses, SCAs, and other immunoreactants.

摘要

背景

早期活动性银屑病皮损的一个特征性表现是中性粒细胞向表皮内浸润，并伴有Munro-Saboureau微脓肿形成。既往免疫荧光研究显示，银屑病患者的Munro-Saboureau微脓肿内存在角质层抗体（SCA）的体内结合反应。

目的

在本研究中，我们旨在探究SCA与Munro-Saboureau微脓肿之间是否存在相关性。

材料与方法

我们研究了50例有Munro-Saboureau微脓肿的银屑病存档活检标本，并试图通过免疫组织化学染色来证实这些微脓肿内抗体的共定位情况。作为对照，我们使用了50例接受美容整形手术的健康患者的皮肤活检标本。

结果

在Munro-Saboureau微脓肿内，相对于对照组，以下标志物在统计学上具有显著阳性：CD1a、CD8、CD23、环氧化酶-2、髓样组织细胞抗原、白蛋白、纤维蛋白原、κ链、λ链、血管性血友病因子、IgG、IgM、IgD、补体/C3c、C3d、髓过氧化物酶和癌胚抗原（P < 0.05）。还检测到对血管的自身反应性，伴有多种免疫球蛋白和补体因子。