莎草根茎对扑热息痛诱导的大鼠肝损伤的保肝活性。

Hepatoprotective activity of Cyperus tegetum rhizome against paracetamol-induced liver damage in rats.

作者信息

Haldar Pallab K, Bera Samit, Panda Siva P, Bhattacharya Sanjib, Chaulya Nitai C, Mukherjee Arup

机构信息

Jadavpur University.

出版信息

J Complement Integr Med. 2011 Jan;8. doi: 10.2202/1553-3840.1398.

DOI:10.2202/1553-3840.1398

PMID:22754940

Abstract

In present study the methanol extract of Cyperus tegetum rhizome (MECT) was evaluated for its effect on paracetamol-induced liver damage in Wistar rats. Serum biochemical parameters viz. serum glutamine oxaloacetate transaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total serum protein, total bilirubin content and liver biochemical parameters such as thiobarbituric acid reactive substances (TBARS) and reduced glutathione content were estimated. Biochemical and histopathological observations indicated that MECT had remarkable hepatoprotective effect against paracetamol-induced liver damage in rats.

摘要

在本研究中，对莎草科植物莎草块茎的甲醇提取物（MECT）在Wistar大鼠中对扑热息痛诱导的肝损伤的影响进行了评估。测定了血清生化参数，即血清谷草转氨酶（SGOT）、血清谷丙转氨酶（SGPT）、血清碱性磷酸酶（ALP）、总血清蛋白、总胆红素含量以及肝脏生化参数，如硫代巴比妥酸反应性物质（TBARS）和还原型谷胱甘肽含量。生化和组织病理学观察表明，MECT对大鼠扑热息痛诱导的肝损伤具有显著的肝保护作用。