Kumar G, Banu G Sharmila, Kannan V, Pandian M Rajasekara
Department of Life Science, Selvamm Arts and Science College, Namakkal, India.
Indian J Exp Biol. 2005 Apr;43(4):351-5.
Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels. Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC.
扑热息痛诱导后血清谷氨酸草酰乙酸转氨酶（SGOT）、血清谷氨酸丙酮酸转氨酶（SGPT）和碱性磷酸酶（ALP）的酶水平升高，而由于用β-胡萝卜素（BC）预处理，这些酶水平显著降低。这种补充剂逆转了胆红素和尿素水平显著降低的趋势。扑热息痛给药显著降低了肝糖原、谷胱甘肽（GSH）、谷胱甘肽-S-转移酶（GST）、谷胱甘肽过氧化物酶（GPX）和谷胱甘肽还原酶（GSH-R）。用BC预处理大鼠显著提高了酶活性。结果表明BC具有肝脏保护活性。
