Manosroi Jiradej, Zaruwa Moses Z, Manosroi Aranya
Chiang Mai University.
J Complement Integr Med. 2011 Jan;8. doi: 10.2202/1553-3840.1482.
The objective of this paper was to investigate the phytochemistry and hypoglycemic activities of aqueous extracts of Anisopus mannii, Daniella olivieri, Detarium macrocarpum, Leptedenia hastate and Mimosa invisa, traditionally prescribed for diabetes mellitus. The aqueous extracts were tested for phytochemicals and free radical scavenging activity by the DPPH assay. The antidiabetic tests were performed in normoglycemic and alloxan induced diabetic mice. High intensity of saponins, xanthones, tannins and glycosides were detected in A. mannii, D. macrocarpum and M. invisa, respectively. For the free radical scavenging activity, D. macrocarpum showed the highest activity with an IC50 of 0.027 mg/ml which was 2.1 folds of ascorbic acid. All extracts showed potent hypoglycemic effects in alloxan induced diabetic mice with the highest fasting blood glucose reduction of 70.39 percent in A. mannii which was 1.54 and 0.98 fold of glibenclamide and human insulin, respectively. A. mannii showed the potent hypoglycemic activity which was 1.54 and 0.98 fold of glibenclamide and insulin, respectively. This study confirmed the traditional use of these Nigerian medicinal plants in diabetes treatment. These plants showed high potential for further investigation to novel anti-diabetic drugs.
本文的目的是研究传统上用于治疗糖尿病的曼氏异萼木、奥利弗丹尼拉木、大果马鞍树、戟叶羊蹄甲和含羞草的水提取物的植物化学性质和降血糖活性。通过DPPH法对水提取物进行植物化学物质和自由基清除活性测试。在血糖正常和四氧嘧啶诱导的糖尿病小鼠中进行抗糖尿病测试。分别在曼氏异萼木、大果马鞍树和含羞草中检测到高强度的皂苷、呫吨酮、单宁和糖苷。对于自由基清除活性，大果马鞍树表现出最高活性，IC50为0.027 mg/ml，是抗坏血酸的2.1倍。所有提取物在四氧嘧啶诱导的糖尿病小鼠中均表现出显著的降血糖作用，曼氏异萼木的空腹血糖降低幅度最高，为70.39%，分别是格列本脲和人胰岛素的1.54倍和0.98倍。曼氏异萼木表现出显著的降血糖活性，分别是格列本脲和胰岛素的1.54倍和0.98倍。本研究证实了这些尼日利亚药用植物在糖尿病治疗中的传统用途。这些植物具有进一步研究开发新型抗糖尿病药物的巨大潜力。
