Mechanism of the ketoconazole-cyclosporin interaction.

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作者信息

Ah-Sing E, Poole T W, Ioannides C, King L J

机构信息

Biochemistry Dept., University of Surrey, Guildford, UK.

出版信息

Arch Toxicol. 1990;64(6):511-3. doi: 10.1007/BF01977638.

DOI:10.1007/BF01977638

PMID:2275609

Abstract

摘要

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引用本文的文献

Combining cytochrome P-450 3A4 modulators and cyclosporine or everolimus in transplantation is successful.在移植中联合使用细胞色素P-450 3A4调节剂与环孢素或依维莫司是成功的。

World J Transplant. 2015 Dec 24;5(4):338-47. doi: 10.5500/wjt.v5.i4.338.

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Drug interactions with cimetidine.西咪替丁的药物相互作用。

Clin Pharmacokinet. 1982 Jan-Feb;7(1):23-41. doi: 10.2165/00003088-198207010-00002.

Disposition of cyclosporine in several animal species and man. I. Structural elucidation of its metabolites.环孢素在几种动物物种和人类中的处置。I. 其代谢产物的结构解析。

Drug Metab Dispos. 1984 Jan-Feb;12(1):120-6.

Cyclosporin interaction with ketoconazole and melphalan.环孢素与酮康唑和马法兰的相互作用。

Lancet. 1982 Dec 11;2(8311):1342. doi: 10.1016/s0140-6736(82)91544-6.

Ketoconazole and cyclosporin.

Lancet. 1982 Nov 27;2(8309):1217. doi: 10.1016/s0140-6736(82)91231-4.

Ketoconazole, cyclosporin metabolism, and renal transplantation.

Lancet. 1982 Oct 16;2(8303):882-3. doi: 10.1016/s0140-6736(82)90851-0.

Metabolism of cyclosporine.

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Pharmacokinetics and dose proportionality of ketoconazole in normal volunteers.酮康唑在正常志愿者体内的药代动力学及剂量比例关系。

Antimicrob Agents Chemother. 1986 Aug;30(2):206-10. doi: 10.1128/AAC.30.2.206.

Cyclosporin-phenytoin interaction: re-evaluation using metabolite data.环孢素与苯妥英钠的相互作用：利用代谢物数据进行重新评估

Br J Clin Pharmacol. 1987 Sep;24(3):329-34. doi: 10.1111/j.1365-2125.1987.tb03177.x.

Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins.咪唑类抗真菌药物与纯化的细胞色素P-450蛋白的相互作用。

Biochem Pharmacol. 1987 Dec 15;36(24):4277-81. doi: 10.1016/0006-2952(87)90670-8.

Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450.

Xenobiotica. 1987 Nov;17(11):1315-27. doi: 10.3109/00498258709047162.

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