环孢素与苯妥英钠的相互作用：利用代谢物数据进行重新评估
Cyclosporin-phenytoin interaction: re-evaluation using metabolite data.
作者信息
Rowland M, Gupta S K
机构信息
Department of Pharmacy, University of Manchester.
出版信息
Br J Clin Pharmacol. 1987 Sep;24(3):329-34. doi: 10.1111/j.1365-2125.1987.tb03177.x.
Abstract
1 Freeman et al. (1984) evoked enzyme induction to explain the lower plasma concentration of cyclosporin following phenytoin co-administration in man. 2 We have examined the whole blood concentration data of two metabolites of cyclosporin, as well as unchanged drug, all measured by h.p.l.c., associated with the above mentioned study. 3 Phenytoin produced no significant effect on either the terminal half-life of both metabolites or the ratio of area under the concentration-time curve of metabolite to parent drug. 4 These data strongly suggest that phenytoin reduces the absorption of cyclosporin; they do not generally support the idea that phenytoin induces cyclosporin metabolism.
摘要
- 弗里曼等人（1984年）通过诱导酶来解释在人体中苯妥英与环孢素联合使用后环孢素血浆浓度较低的现象。2. 我们检查了与上述研究相关的环孢素两种代谢物以及未改变药物的全血浓度数据，所有数据均通过高效液相色谱法测量。3. 苯妥英对两种代谢物的终末半衰期或代谢物浓度 - 时间曲线下面积与母体药物的比值均无显著影响。4. 这些数据有力地表明苯妥英降低了环孢素的吸收；它们总体上不支持苯妥英诱导环孢素代谢的观点。
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本文引用的文献
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