[Changes in the cell pool of the intramural neural plexus of the large intestine during postnatal development].

Using a complex of morphological, morphometrical and histochemical methods, morphofunctional regularities for the age-related changes in the cell pool of intramural (myenteric and submucosal) nervous plexuses have been studied in the large intestine of albino rats during postnatal development. Three periods in development and differentiation of neurocellular resources of the intestine have been distinguished: progressive growth, relative stabilization and regressive phenomena. Peculiarities in structural-chemical transformation of cellular elements have been revealed during each period. Reduction of the cell pool of plexuses, as well as development of adaptive compensatory processes take place with ageing. The role of denervation of the organ in development of age-related functional disorders is discussed.