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Relationship between inhibition of protein methylase I and inhibition of Rous sarcoma virus-induced cell transformation.

作者信息

Enouf J, Lawrence F, Tempete C, Robert-Gero M, Lederer E

出版信息

Cancer Res. 1979 Nov;39(11):4497-502.

PMID:227587
Abstract

A correlation was found between inhibition of protein methylase I and inhibition of virus-induced cell transformation by structural analogs of S-adenosylhomocysteine; all good inhibitors of this enzyme are also good inhibitors of Rous sarcoma virus-induced chicke embryo fibroblast transformation. The inhibitory effect of these analogs was similar on enzymes from normal and transformed cells; no significant variation of the inhibition constants was observed after purification of protein methylase I. From the kinetic constants obtained, a structure-activity relationship can be established for protein methylase I.

摘要

相似文献

1
Relationship between inhibition of protein methylase I and inhibition of Rous sarcoma virus-induced cell transformation.
Cancer Res. 1979 Nov;39(11):4497-502.
2
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Effect of analogues of 5'-methylthioadenosine on cellular metabolism. Inactivation of S-adenosylhomocysteine hydrolase by 5'-isobutylthioadenosine.
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