Division of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-Dong, Songpa-gu, Seoul 138-736, South Korea.
Respirology. 2012 Oct;17(7):1125-30. doi: 10.1111/j.1440-1843.2012.02218.x.
The results of tuberculin skin tests (TST) and QuantiFERON TB-Gold In-Tube (QFT-GIT) assays were compared in close contacts of patients with multidrug-resistant tuberculosis (MDR-TB).
Close contacts of patients with bacteriologically confirmed MDR-TB (n = 101) were assessed. Most contacts were members of the households of patients, and 79 (78.2%) had received Bacille Calmette-Guerin (BCG) vaccination. Samples from each contact were tested using the TST and the QFT-GIT assay on the same day, and the concordance between these results was assessed using kappa (κ) coefficients.
Forty-eight subjects (47.5%) showed positive responses on TST, using a 10-mm induration cut-off, and 54 (53.5%) were positive for the QFT-GIT assay. Of the 48 individuals who were TST positive, 34 (70.8%) were positive for the QFT-GIT assay. Of the 53 subjects who were TST negative, 33 (62.5%) were negative for the QFT-GIT assay. The overall agreement between the two tests (κ coefficient) was 0.33. The κ coefficient was higher in the 22 subjects who had not received BCG vaccination (κ = 0.48) than in the 79 subjects who had received BCG vaccination (κ = 0.29).
The TST and QFT-GIT assays showed poor correlation in close contacts of patients with MDR-TB, especially those contacts who had received BCG vaccination.
比较结核菌素皮肤试验（TST）和 QuantiFERON TB-Gold In-Tube（QFT-GIT）检测在耐多药结核病（MDR-TB）患者的密切接触者中的结果。
评估了经细菌学证实的 MDR-TB 患者的 101 名密切接触者。大多数接触者是患者的家庭成员，79 名（78.2%）接受过卡介苗（BCG）接种。同一天对每个接触者的样本进行 TST 和 QFT-GIT 检测，并使用κ（κ）系数评估这些结果的一致性。
48 名受试者（47.5%）在 TST 上使用 10mm 硬结截断值显示阳性反应，54 名（53.5%）对 QFT-GIT 检测呈阳性。在 48 名 TST 阳性的个体中，34 名（70.8%）对 QFT-GIT 检测呈阳性。在 53 名 TST 阴性的受试者中，33 名（62.5%）对 QFT-GIT 检测呈阴性。两种检测方法的总体一致性（κ 系数）为 0.33。在未接受 BCG 接种的 22 名受试者中（κ=0.48），κ 系数高于接受 BCG 接种的 79 名受试者（κ=0.29）。
TST 和 QFT-GIT 检测在 MDR-TB 患者的密切接触者中相关性较差，尤其是那些接受过 BCG 接种的接触者。
