镍催化三唑并吡啶的烯基化反应：2,6-二取代吡啶的合成。
Ni-catalyzed alkenylation of triazolopyridines: synthesis of 2,6-disubstituted pyridines.
机构信息
Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607-7061, United States.
出版信息
Org Lett. 2012 Jul 20;14(14):3744-7. doi: 10.1021/ol301606y. Epub 2012 Jul 3.
PMID:22758932
Abstract
A synthetic strategy to access 2,6-disubstituted pyridines from triazolopyridines through a regioselective nickel-catalyzed alkenylation reaction of the C7-H bond is described. The N2 fragment embedded in the resulting C-H functionalized triazolopyridine can be readily excised using acidic or oxidative conditions to unmask the pyridine.
摘要
描述了一种通过 C7-H 键的区域选择性镍催化烯基化反应从三唑并吡啶中获得 2,6-二取代吡啶的合成策略。使用酸性或氧化条件可以很容易地切除嵌入在所得 C-H 官能化三唑并吡啶中的 N2 片段，从而暴露出吡啶。
Zotero 插件