Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Hannover, Germany.
Dermatol Surg. 2012 Jul;38(7 Pt 2):1136-42. doi: 10.1111/j.1524-4725.2012.02466.x.
In spite of potential implications for anti-aging therapy regarding the selection of the most suitable therapeutical method and potential perinterventional complications, cutaneous microcirculation of the aging hand in healthy individuals as well as in those with diabetes mellitus or peripheral arterial occlusive disease (PAOD) has never been evaluated.
Functional microcirculation of the dorsal hand differs between healthy individuals and individuals with diabetes or PAOD at the same age.
Prospective controlled cohort study. One hundred ten individuals were allocated to group A (healthy individuals, n = 37), group B (diabetes mellitus, n = 36), and group C (PAOD, n = 37). Microcirculatory data were obtained using combined laser-Doppler and photospectrometry.
Cutaneous oxygen saturation at the dorsal hand of healthy individuals was 11.1% higher than of those with diabetes mellitus (p = .04) and 18.8% higher than of those with PAOD (p = .001). Cutaneous capillary blood flow in participants with PAOD was 20% higher than in healthy individuals (p = .047).
This is the first study demonstrating that capillary microcirculation of the dorsal hand differs between healthy individuals and those with diabetes or PAOD of the same age. Further studies should explore whether ameliorating cutaneous tissue oxygen saturation could emerge as a viable antiaging strategy for elderly hands.
尽管对于抗衰老治疗而言，选择最合适的治疗方法和潜在的介入并发症具有重要意义，但健康个体以及糖尿病或外周动脉闭塞性疾病（PAOD）患者手部的皮肤微循环尚未得到评估。
健康个体、糖尿病患者和 PAOD 患者手部背侧的功能性微循环存在差异。
前瞻性对照队列研究。110 名个体被分为 A 组（健康个体，n = 37）、B 组（糖尿病，n = 36）和 C 组（PAOD，n = 37）。使用激光多普勒和光光谱法联合获得微循环数据。
健康个体手部背侧皮肤氧饱和度比糖尿病患者高 11.1%（p =.04），比 PAOD 患者高 18.8%（p =.001）。PAOD 患者的皮肤毛细血管血流比健康个体高 20%（p =.047）。
这是第一项表明健康个体与同龄糖尿病或 PAOD 患者手部背侧毛细血管微循环存在差异的研究。进一步的研究应探讨改善皮肤组织氧饱和度是否可以成为老年人手部抗衰老的可行策略。
