Jenkins C D, McDonnell P J, Spalton D J
Department of Ophthalmology, St Thomas's Hospital, London.
Br J Ophthalmol. 1990 Dec;74(12):734-8. doi: 10.1136/bjo.74.12.734.
Comparatively little attention has been paid to the conjunctival toxicity of antibiotics administered at the time of cataract surgery. We have observed the effect of subconjunctival gentamicin and cefuroxime injection, using colour photography in a randomised single blind trial of 121 patients undergoing routine cataract surgery. Our results suggest that a hyperaemic eye is likely to occur about twice as often in patients injected with gentamicin (p less than 0.001). Gentamicin is associated with more pain postoperatively (p less than 0.05). Significant manifestations of gentamicin toxicity are conjunctival oedema and capillary closure. Cefuroxime has some theoretical advantages over gentamicin in its antibacterial spectrum.
相对而言，白内障手术时使用的抗生素对结膜的毒性很少受到关注。在一项对121例行常规白内障手术患者的随机单盲试验中，我们通过彩色摄影观察了结膜下注射庆大霉素和头孢呋辛的效果。我们的结果表明，注射庆大霉素的患者出现充血性眼睛的几率可能是未注射患者的两倍左右（p<0.001）。庆大霉素与术后更多疼痛相关（p<0.05）。庆大霉素毒性的显著表现为结膜水肿和毛细血管闭塞。头孢呋辛在抗菌谱方面比庆大霉素具有一些理论优势。
