Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal.
Rev Soc Bras Med Trop. 2012 Jun;45(3):369-74. doi: 10.1590/s0037-86822012000300017.
Malaria during pregnancy remains a serious public health problem. The aim of this study was to establish the prevalence and possible risk factors for malaria in pregnant women attending antenatal care at Augusto Ngangula Specialized General Hospital in Luanda, Angola.
Pregnant women (679 total) who attended antenatal care from April to September 2008 were included in the study after signing informed consent. For each participant, the social-demographic profile and malaria and obstetric histories were investigated via a questionnaire. Diagnosis was made by optic microscopy, and hemoglobin concentration measured. The associations between age, parity, gestational age, residence, schooling, malaria during gravity, anemia and treatment with incidence of Plasmodium falciparum infection were analyzed through logistic regression.
During the period of study, 74 (10.9%) out of 679 women were infected by P. falciparum. The average concentration of hemoglobin was 11.1 ± 0.07 g/dL, and there were significant associations between the history of malaria during pregnancy, P. falciparum infection (p<0.01) and anemia at the time of observation (p<0.001).
Previous history of malaria during pregnancy represents a risk factor for current infection and anemia was an important complication associated with malaria, even in women who were treated with sulfadoxine-pyrimethamine during pregnancy.
怀孕期间疟疾仍然是一个严重的公共卫生问题。本研究的目的是确定安哥拉罗安达奥古斯托·恩冈古拉专科医院产前护理孕妇疟疾的患病率和可能的危险因素。
2008 年 4 月至 9 月期间接受产前护理的孕妇（共 679 人）在签署知情同意书后纳入研究。对于每一位参与者，通过问卷调查社会人口学特征以及疟疾和产科病史。通过光学显微镜诊断，并测量血红蛋白浓度。通过逻辑回归分析年龄、产次、孕龄、居住地、受教育程度、怀孕期间疟疾、贫血与裂殖体疟原虫感染发生率之间的关系。
在研究期间，679 名妇女中有 74 名（10.9%）感染了恶性疟原虫。平均血红蛋白浓度为 11.1±0.07 g/dL，怀孕期间疟疾史、恶性疟原虫感染（p<0.01）和观察时贫血（p<0.001）之间存在显著关联。
怀孕期间的疟疾史是当前感染的危险因素，贫血是与疟疾相关的一个重要并发症，即使孕妇在怀孕期间接受了磺胺多辛-乙胺嘧啶治疗也是如此。
