Cisse Mamoudou, Sangare Ibrahim, Lougue Guekoun, Bamba Sanata, Bayane Dramane, Guiguemde Robert Tinga
BMC Infect Dis. 2014 Nov 19;14:631. doi: 10.1186/s12879-014-0631-z.
Malaria during pregnancy remains a serious public health problem. The aim of this study was to determine the prevalence and possible risk factors for malaria in pregnant women attending antenatal clinic at two primary health facilities in Bobo-Dioulasso.
We conducted a cross sectional study from September to December 2010 in two primary health facilities located in the periurban area of Bobo-Dioulasso. Pregnant women attending antenatal clinic (ANC) were included in the study after signing informed consent. For each participant, the social-demographic profile, malaria and obstetric histories were investigated through a questionnaire. Peripheral blood was collected and thick and thin blood smears were prepared to check Plasmodium falciparum parasitaemia. Hemoglobin concentration was measured. The associations between age, parity, gestational age, schooling, number of ANC visits, use of IPTp-SP, use of insecticide-treated nets (ITN) and anemia with the occurrence of P. falciparum malaria infection during pregnancy were analyzed through logistic regression.
During the period of study, 105 (18.1%) out of 579 pregnant women were infected by P. falciparum. The hemoglobin concentration mean was 10.5 ± 1.7/dL and was significantly lower in pregnant women with malaria infection (9.8 g/dL ±1.6) than in those who had no malaria infection (10.6 g/dL ±1.7) (P < 0.001). Multivariate analysis indicated that, education (AOR 1.9, 95% CI = [1.2-3.2]), parity [primigravidae (AOR 5.0, 95% CI = [2.5-9.8]) and secundigravidae (AOR 2.1, 95% CI = [1.2-3.8])], and anaemia (AOR 2.1, 95% CI = [1.3-3.5]) were significantly associated with P. falciparum malaria infection. The use of IPTp-SP was not associated with P. falciparum malaria infection.
P. falciparum malaria infection is common in pregnant women attending antenatal clinic and anaemia is an important complication. The results show that the use of IPTp-SP does not reduce the risk of malaria incidence during pregnancy.
妊娠疟疾仍然是一个严重的公共卫生问题。本研究的目的是确定在博博迪乌拉索的两个初级卫生机构就诊的孕妇中疟疾的患病率及可能的危险因素。
2010年9月至12月，我们在博博迪乌拉索城郊地区的两个初级卫生机构进行了一项横断面研究。签署知情同意书后，在产前诊所就诊的孕妇被纳入研究。通过问卷调查，对每位参与者的社会人口学特征、疟疾和产科病史进行调查。采集外周血，制备厚血涂片和薄血涂片以检查恶性疟原虫血症。测量血红蛋白浓度。通过逻辑回归分析年龄、产次、孕周、受教育程度、产前检查次数、间歇性预防治疗（IPTp-SP）的使用、经杀虫剂处理的蚊帐（ITN）的使用以及贫血与孕期恶性疟原虫感染发生之间的关联。
在研究期间，579名孕妇中有105名（18.1%）感染了恶性疟原虫。血红蛋白浓度平均值为10.5±1.7g/dL，疟疾感染孕妇的血红蛋白浓度（9.8g/dL±1.6）显著低于未感染疟疾的孕妇（10.6g/dL±1.7）（P<0.001）。多因素分析表明，受教育程度（调整后比值比[AOR]1.9，95%置信区间[CI]=[1.2 - 3.2]）、产次[初产妇（AOR 5.0，95%CI=[2.5 - 9.8]）和经产妇（AOR 2.1，95%CI=[1.2 - 3.8]）]以及贫血（AOR 2.1，95%CI=[1.3 - 3.5]）与恶性疟原虫感染显著相关。IPTp-SP的使用与恶性疟原虫感染无关。
在产前诊所就诊的孕妇中，恶性疟原虫感染很常见，贫血是一种重要的并发症。结果表明，IPTp-SP的使用并不能降低孕期疟疾发病风险。
