Inhibition of the transformation-specific kinase in ASV-transformed cells by N-alpha-tosyl-L-lysyl chloromethyl ketone.

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作者信息

Richert N, Davies P J, Jay G, Pastan I

出版信息

Cell. 1979 Oct;18(2):369-74. doi: 10.1016/0092-8674(79)90056-4.

DOI:10.1016/0092-8674(79)90056-4

PMID:227606

Abstract

摘要

相似文献

Inhibition of the transformation-specific kinase in ASV-transformed cells by N-alpha-tosyl-L-lysyl chloromethyl ketone.

Cell. 1979 Oct;18(2):369-74. doi: 10.1016/0092-8674(79)90056-4.

N-alpha-Tosyl-L-lysine chloromethyl ketone and N-alpha-tosyl-L-phenylalanine chloromethyl ketone inhibit protein kinase C.N-α-对甲苯磺酰-L-赖氨酸氯甲基酮和N-α-对甲苯磺酰-L-苯丙氨酸氯甲基酮可抑制蛋白激酶C。

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Differential inhibition of globin chain synthesis by tosyl-L-lysyl chloromethyl ketone.甲苯磺酰-L-赖氨酰氯甲基酮对珠蛋白链合成的差异性抑制作用。

Life Sci. 1981 Nov 2;29(18):1873-9. doi: 10.1016/0024-3205(81)90518-x.

Inactivation of cyclic GMP-dependent protein kinase by N alpha-tosyl-L-lysine chloromethylketone.Nα-对甲苯磺酰-L-赖氨酸氯甲基酮对环磷酸鸟苷依赖性蛋白激酶的失活作用。

Life Sci. 1981 Sep 21;29(12):1235-41. doi: 10.1016/0024-3205(81)90228-9.

Effects of N alpha-tosyl-L-lysyl-chloromethylketone on the activity of cytotoxic T lymphocytes.Nα-对甲苯磺酰-L-赖氨酰氯甲基酮对细胞毒性T淋巴细胞活性的影响。

J Immunol. 1980 Mar;124(3):1028-33.

Inhibition of initiation of protein synthesis by tosyl-L-lysyl chloromethyl ketone.

Can J Biochem. 1981 May;59(5):321-7. doi: 10.1139/o81-045.

Secretion of proteins from liver cells is suppressed by the proteinase inhibitor N-alpha-tosyl-L-lysyl chloromethane, but not by tunicamycin, an inhibitor of glycosylation.肝细胞分泌蛋白质受到蛋白酶抑制剂N-α-甲苯磺酰-L-赖氨酰氯甲烷的抑制，但不受糖基化抑制剂衣霉素的抑制。

FEBS Lett. 1979 Apr 15;100(2):269-72. doi: 10.1016/0014-5793(79)80349-x.

The effect of TLCK on transcription and its role in modifying cell growth.

J Cell Physiol. 1977 Jul;92(1):137-43. doi: 10.1002/jcp.1040920116.

Evidence for an active-center cysteine in the SH-proteinase alpha-clostripain through use of N-tosyl-L-lysine chloromethyl ketone.通过使用N-对甲苯磺酰-L-赖氨酸氯甲基酮证明SH蛋白酶α-梭菌蛋白酶中存在活性中心半胱氨酸。

FEBS Lett. 1984 Jul 23;173(1):58-62. doi: 10.1016/0014-5793(84)81017-0.

Affinity labeling of the catalytic subunit of cyclic AMP-dependent protein kinase by N alpha-tosyl-L-lysine chloromethyl ketone.用Nα-对甲苯磺酰-L-赖氨酸氯甲基酮对环磷酸腺苷依赖性蛋白激酶催化亚基进行亲和标记。

Proc Natl Acad Sci U S A. 1979 Jul;76(7):3073-7. doi: 10.1073/pnas.76.7.3073.

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In vitro effects of protease inhibitors on murine natural killer cell activity.蛋白酶抑制剂对小鼠自然杀伤细胞活性的体外作用。

Immunology. 1983 Jan;48(1):1-8.

Membranes from T and B lymphocytes have different patterns of tyrosine phosphorylation.T淋巴细胞和B淋巴细胞的细胞膜具有不同的酪氨酸磷酸化模式。

Proc Natl Acad Sci U S A. 1984 Apr;81(8):2347-51. doi: 10.1073/pnas.81.8.2347.

Purified low-molecular-weight protein kinase from murine sarcoma virus particles catalyzes tyrosine phosphorylation endogenously but phosphorylates cellular proteins at serine.从鼠肉瘤病毒颗粒中纯化的低分子量蛋白激酶可内源性催化酪氨酸磷酸化，但能使细胞蛋白在丝氨酸处磷酸化。

J Virol. 1981 Aug;39(2):612-24. doi: 10.1128/JVI.39.2.612-624.1981.

Induction of DNA synthesis in isolated nuclei by cytoplasmic factors: inhibition by protease inhibitors.细胞质因子诱导分离细胞核中的DNA合成：蛋白酶抑制剂的抑制作用

Proc Natl Acad Sci U S A. 1987 Jan;84(1):241-5. doi: 10.1073/pnas.84.1.241.

Purification and characterization of a tyrosine-specific protein kinase of Mr 60,000 and comparison with a kinase of Mr 56,000 from rat spleen.60,000道尔顿酪氨酸特异性蛋白激酶的纯化与特性分析以及与大鼠脾脏中56,000道尔顿激酶的比较

Biochem J. 1988 Apr 15;251(2):569-76. doi: 10.1042/bj2510569.

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