Virk Jasveer, Hsu Paul, Olsen Jørn
Department of Epidemiology, Southern California Injury Prevention Research Center, University of California Los Angeles (UCLA), Los Angeles, UK.
BMJ Open. 2012 Jul 2;2(4). doi: 10.1136/bmjopen-2012-000826. Print 2012.
To describe adverse birth outcomes associated with hospital-treated injuries that took place among women in the Danish National Birth Cohort.
Longitudinal cohort study.
Denmark.
90 452 women and their offspring selected from the Danish National Birth Cohort.
To determine if injured women were more likely to deliver an infant preterm, with low birth weight, stillborn or have a spontaneous abortion, the authors estimated HRs. ORs were generated to assess APGAR scores and infants born small for gestational age (SGA). Models were adjusted for maternal smoking and drinking during pregnancy, household socioeconomic status, eclampsia/pre-eclampsia or gestational diabetes status during pregnancy and maternal age at birth; estimates for preterm birth were also adjusted for prior history of preterm birth.
In the cohort of 90 452 pregnant women, 3561 (3.9%) received medical treatment for an injury during pregnancy. Injured pregnant women were more likely to deliver infants that were stillborn or have pregnancies terminated by spontaneous abortion. The authors did not detect an adverse effect between injuries sustained during pregnancy and delivery of preterm, low birth weight or SGA infants, or infants with an APGAR score of <7.
The study shows that injuries occurring among women from an unselected population may not have an adverse effect on birth weight, gestational age, APGAR score or SGA status but may adversely affect the risk of stillbirth and spontaneous abortions in some situations.
描述丹麦国家出生队列中女性因医院治疗的损伤而导致的不良出生结局。
纵向队列研究。
丹麦。
从丹麦国家出生队列中选取的90452名女性及其后代。
为了确定受伤女性是否更有可能早产、分娩低体重儿、死产或自然流产,作者估计了风险比(HRs)。生成比值比(ORs)以评估阿氏评分和小于胎龄儿(SGA)。模型针对孕期母亲吸烟和饮酒、家庭社会经济状况、孕期子痫前期/子痫或妊娠期糖尿病状况以及母亲生育年龄进行了调整;早产的估计值还针对早产既往史进行了调整。
在90452名孕妇队列中,3561名(3.9%)在孕期接受了损伤治疗。受伤孕妇更有可能分娩死产儿或自然流产。作者未发现孕期受伤与早产、低体重儿或小于胎龄儿的分娩,或阿氏评分<7分的婴儿之间存在不良影响。
该研究表明,未经过筛选的人群中女性发生的损伤可能对出生体重、胎龄、阿氏评分或小于胎龄儿状态没有不良影响,但在某些情况下可能对死产和自然流产风险产生不利影响。