Discipline of Psychiatry, School of Medicine, University of Adelaide, Australia.
Aust N Z J Psychiatry. 2012 Aug;46(8):753-61. doi: 10.1177/0004867412453089. Epub 2012 Jul 3.
To determine the prevalence of cardiometabolic risk factors in Australian adults with a psychotic disorder.
Data were collected during the interview phase of the second Australian survey of psychosis, a population-based survey of Australians aged 18 to 64 years with a psychotic disorder. Body mass index, waist circumference and blood pressure were measured. Participants were asked about diagnoses of relevant medical conditions, medications, smoking and physical activity. Fasting blood samples were analysed for glucose, high-density lipoprotein cholesterol, total cholesterol and triglycerides. The prevalence of metabolic syndrome was determined using the harmonized criteria developed by the International Diabetes Federation and other bodies.
A total of 1087 men (60%) and 738 women (40%) participated. Their mean age was 38.36 (SD 11.16) years; 773 (42%) were aged 18-34 years and 1052 (58%) 35-64 years. Three-quarters were overweight or obese and 82% had abdominal obesity. Almost half were hypertensive. Two-thirds were current smokers and 81% had a lifetime history of smoking. Levels of physical activity were very low. About 30% reported a diagnosis of hypertension or high cholesterol, 20% knew they had diabetes or high blood sugar and 18% had cardiovascular disease. Half of those with self-reported hypertension were taking antihypertensive drugs, and about 40% with hypercholesterolemia or hyperglycaemia were receiving medication for these conditions. Seventy per cent (N = 1286) of participants provided fasting blood samples. Abnormal levels of high-density lipoprotein cholesterol and triglycerides were each found in almost half of participants and almost one-third had elevated fasting glucose. More than half of participants (54.8%) met criteria for metabolic syndrome.
Australians living with psychosis have high rates of cardiometabolic risk factors. There are a number of obvious targets for prevention and treatment, including obesity (especially in women), smoking (more prevalent in men), hypertension, hyperlipidaemia and sedentary lifestyle.
确定澳大利亚患有精神障碍的成年人中心血管代谢危险因素的流行情况。
数据来自澳大利亚精神障碍第二次调查的访谈阶段，这是一项针对 18 至 64 岁患有精神障碍的澳大利亚人的全国性调查。测量了体重指数、腰围和血压。询问了与相关医疗条件、药物、吸烟和身体活动有关的诊断。采集空腹血样检测血糖、高密度脂蛋白胆固醇、总胆固醇和甘油三酯。使用国际糖尿病联合会和其他机构制定的统一标准确定代谢综合征的患病率。
共有 1087 名男性（60%）和 738 名女性（40%）参与。他们的平均年龄为 38.36（SD 11.16）岁；773 人（42%）年龄在 18-34 岁之间，1052 人（58%）年龄在 35-64 岁之间。四分之三的人超重或肥胖，82%的人有腹部肥胖。近一半的人患有高血压。三分之二的人是当前吸烟者，81%的人有吸烟史。身体活动水平非常低。约 30%的人报告有高血压或高胆固醇的诊断，20%的人知道自己患有糖尿病或高血糖，18%的人患有心血管疾病。报告有高血压的人中有一半在服用降压药，约 40%的高胆固醇血症或高血糖症患者正在服用这些疾病的药物。70%（N=1286）的参与者提供了空腹血样。几乎一半的参与者高密度脂蛋白胆固醇和甘油三酯水平异常，近三分之一的人空腹血糖升高。超过一半的参与者（54.8%）符合代谢综合征的标准。
澳大利亚精神病患者中心血管代谢危险因素的发生率很高。有许多明显的预防和治疗目标，包括肥胖（尤其是女性）、吸烟（男性更为普遍）、高血压、血脂异常和久坐的生活方式。
