Vannest Jennifer, Szaflarski Jerzy P, Eaton Kenneth P, Henkel David M, Morita Diego, Glauser Tracy A, Byars Anna W, Patel Krishna, Holland Scott K
Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
J Child Neurol. 2013 Apr;28(4):435-45. doi: 10.1177/0883073812447682. Epub 2012 Jul 2.
In children with benign childhood epilepsy with centrotemporal spikes, centrotemporal spikes may cause language dysfunction via disruption of underlying functional neuroanatomy. Fifteen patients with benign childhood epilepsy with centrotemporal spikes and 15 healthy controls completed 3 functional magnetic resonance imaging (MRI) language paradigms; standardized cognitive and language assessments were also performed. For all paradigms, children with benign childhood epilepsy with centrotemporal spikes showed specific regional differences in activation compared to controls. Children with benign childhood epilepsy with centrotemporal spikes also differed from controls on neuropsychological testing. They did not differ in general intelligence, but children with benign childhood epilepsy with centrotemporal spikes scored significantly lower than controls on tests of language, visuomotor integration, and processing speed. These results extend previous findings of lower language and cognitive skills in patients with benign childhood epilepsy with centrotemporal spikes, and suggest epilepsy-related remodeling of language networks that may underlie these observed differences.
在具有中央颞区棘波的儿童良性癫痫患儿中，中央颞区棘波可能通过破坏潜在的功能神经解剖结构而导致语言功能障碍。15例具有中央颞区棘波的儿童良性癫痫患儿和15名健康对照完成了3种功能磁共振成像（MRI）语言范式；还进行了标准化的认知和语言评估。对于所有范式，具有中央颞区棘波的儿童良性癫痫患儿与对照相比在激活方面表现出特定的区域差异。具有中央颞区棘波的儿童良性癫痫患儿在神经心理学测试中也与对照不同。他们在一般智力方面没有差异，但具有中央颞区棘波的儿童良性癫痫患儿在语言、视觉运动整合和处理速度测试中的得分显著低于对照。这些结果扩展了先前关于具有中央颞区棘波的儿童良性癫痫患者语言和认知技能较低的发现，并提示可能是这些观察到的差异基础的癫痫相关语言网络重塑。
